Affinity selection–mass spectrometry with linearizable macrocyclic peptide libraries
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DOI: 10.1126/sciadv.adr1018
Abstract: Despite their potential, the preparation of large synthetic macrocyclic libraries for ligand discovery and development has been limited. Here, we produce 100-million-membered macrocyclic libraries containing natural and nonnatural amino acids. Near-quantitative intramolecular disulfide formation is… read more here.
Keywords: macrocyclic libraries; affinity selection; mass spectrometry; affinity ... See more keywords