Thermodynamic characterization of a macrocyclic Zika virus NS2B/NS3 protease inhibitor and its acyclic analogs
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DOI: 10.1002/ardp.202200518
Abstract: Cyclization of small molecules is a widely applied strategy in drug design for ligand optimization to improve affinity, as it eliminates the putative need for structural preorganization of the ligand before binding, or to improve… read more here.
Keywords: virus ns2b; macrocyclic zika; zika virus; protease inhibitor ... See more keywords