MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors.
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DOI: 10.1158/2159-8290.cd-17-0909
Abstract: ADP-ribosylation is an important posttranslational protein modification that regulates diverse biological processes, controlled by dedicated transferases and hydrolases. Here, we show that frequent deletions (∼30%) of the MACROD2 mono-ADP-ribosylhydrolase locus in human colorectal cancer cause… read more here.
Keywords: cancer; activity; macrod2 haploinsufficiency; chromosome instability ... See more keywords