Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV-2 Macrodomain
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DOI: 10.1021/acsmedchemlett.0c00684
Abstract: The nsP3 macrodomain is a conserved protein interaction module that plays essential regulatory roles in the host immune response by recognizing and removing posttranslational ADP-ribosylation sites during SARS-CoV-2 infection. Thus targeting this protein domain may… read more here.
Keywords: macrodomain structural; cov macrodomain; structural insights; insights plasticity ... See more keywords