Late-stage macrolactonisation enabled by tandem acyl transfers followed by desulphurisation.
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DOI: 10.1039/d1cc07248j
Abstract: Intramolecular S-acylation of a thiol-installed threonine with a thioester unit, followed by S-O acyl transfer and subsequent desulphurisation, allows the synthesis of lactone peptides. A protocol has been developed enabling the cyclisation of a linear… read more here.
Keywords: macrolactonisation enabled; desulphurisation; tandem acyl; enabled tandem ... See more keywords