Towards a Rational Design of Macrolide Antibiotics in Order to Combat Bacterial Resistance
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1749
Abstract: Macrolides, which bind in the protein exit tunnel of the bacterial ribosome, are one of the most prescribed classes of antibiotics.However, macrolide resistance caused by ribosomal modifications at base A2058 in segment 23S is a… read more here.
Keywords: macrolide; bacterial resistance; towards rational; resistance ... See more keywords
Macrolide-resistant Mycoplasma pneumoniae in South Korea: a strong association with M. pneumoniae type 1
Sign Up to like & getrecommendations! Published in 2019 at "Epidemiology and Infection"
DOI: 10.1017/s0950268819002000
Abstract: Abstract Mycoplasma pneumoniae is a main pathogen causing community-acquired pneumonia in children and young adults. Since the emergence of macrolide-resistant M. pneumoniae in the early 2000s in Japan, it has been increasingly reported worldwide as… read more here.
Keywords: macrolide; mycoplasma pneumoniae; pneumoniae; macrolide resistant ... See more keywords
Macrolide resistance of Mycoplasma pneumoniae in several regions of China from 2013 to 2019
Sign Up to like & getrecommendations! Published in 2024 at "Epidemiology and Infection"
DOI: 10.1017/s0950268824000323
Abstract: Abstract This paper retrospectively analysed the prevalence of macrolide-resistant Mycoplasma pneumoniae (MRMP) in some parts of China. Between January 2013 and December 2019, we collected 4,145 respiratory samples, including pharyngeal swabs and alveolar lavage fluid.… read more here.
Keywords: macrolide; resistance; rate; macrolide resistant ... See more keywords
Tetracycline- and Macrolide-Resistant Enterococcus Species Isolated from a Mink Farm in the United States.
Sign Up to like & getrecommendations! Published in 2022 at "Microbial drug resistance"
DOI: 10.1089/mdr.2021.0438
Abstract: Enterococcus species are a normal flora of animals and humans. However, life-threatening opportunistic infections can be caused by antimicrobial resistant strains. Fecal (n = 42) and feed (n = 8) samples were obtained from a mink farm and cultured… read more here.
Keywords: tetr; macrolide; enterococcus species; mink farm ... See more keywords
Investigation of Macrolide Resistance Genotypes of Pasteurella multocida Isolates from Cattle and Small Ruminants.
Sign Up to like & getrecommendations! Published in 2022 at "Microbial drug resistance"
DOI: 10.1089/mdr.2022.0010
Abstract: Macrolides are commonly used to control respiratory tract infections in ruminants, but the susceptibility of Pasteurella multocida strains has shown a decrease to macrolide antibiotics in the last decade. In this work we assessed the… read more here.
Keywords: macrolide; small ruminants; pasteurella multocida; macrolide resistance ... See more keywords
P-784. Early Prediction of Inducible Macrolide Resistance For Mycobacterium abscessus –Minimum Inhibitory Concentrations at Day 7 Versus Day 14
Sign Up to like & getrecommendations! Published in 2025 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofae631.978
Abstract: Abstract Background Mycobacterium abscessus is notoriously difficult to treat. Current guidelines suggest a 14-day long incubation period and/or sequencing of erm41 to detect inducible macrolide resistance when treating pulmonary disease. However, the lengthy incubation is… read more here.
Keywords: macrolide; resistance; inducible macrolide; abscessus ... See more keywords
Comparative study of clinical characteristics and long-term prognosis between macrolide-resistant and macrolide-sensitive Mycoplasma pneumoniae infections in children: A retrospective case-control study.
Sign Up to like & getrecommendations! Published in 2025 at "Medicine"
DOI: 10.1097/md.0000000000044302
Abstract: This study aimed to investigate the long-term health impacts of macrolide-resistant macrolide-resistant Mycoplasma pneumoniae (MRMP) infection in children, identify factors influencing MRMP infection, and provide evidence for clinical decision-making to improve prognosis and address challenges… read more here.
Keywords: macrolide; long term; group; study ... See more keywords
Men who have sex with men with Mycoplasma genitalium-positive nongonococcal urethritis are more likely to have macrolide resistant strains than men with only female partners: a prospective study.
Sign Up to like & getrecommendations! Published in 2019 at "Sexually Transmitted Diseases"
DOI: 10.1097/olq.0000000000001009
Abstract: BACKGROUND Mycoplasma genitalium was previously less common among men who have sex with men (MSM) compared with men with only female partners (MSW) in men with nongonococcal urethritis (NGU) in Sydney, Australia. We aimed to… read more here.
Keywords: macrolide; resistance; female partners; mycoplasma genitalium ... See more keywords
Macrolide resistance is pervasive in oral streptococci in the Belgian general population: a cross-sectional survey.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of medical microbiology"
DOI: 10.1099/jmm.0.001932
Abstract: Background. Commensal streptococci are common inhabitants of the oral microbiome and regulate its structure and function in beneficial ways for human health. They can, however, also be opportunistic pathogens and act as a reservoir of… read more here.
Keywords: macrolide; resistance; belgian general; streptococci ... See more keywords
Assessment of Long-Term Macrolide Exposure on the Oropharyngeal Microbiome and Macrolide Resistance in Healthy Adults and Consequences for Onward Transmission of Resistance
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02246-21
Abstract: While the use of long-term macrolide therapy to prevent exacerbations in chronic respiratory diseases is widespread, its impact on the oropharyngeal microbiota and macrolide resistance and the potential for onward transmission of resistance to close… read more here.
Keywords: macrolide; long term; macrolide resistance; transmission ... See more keywords
Synergistic impact of macrolide resistance and H3N2 infection on M. pneumoniae outbreak in children
Sign Up to like & getrecommendations! Published in 2025 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01844-24
Abstract: ABSTRACT In November 2023, there was a substantial increase in the incidence of Mycoplasma pneumoniae infections in China following waves of SARS-CoV-2 Omicron variant and influenza outbreaks. This study aimed to elucidate the epidemiological features… read more here.
Keywords: macrolide; h3n2 infection; pneumoniae; pneumoniae outbreak ... See more keywords