Towards a Rational Design of Macrolide Antibiotics in Order to Combat Bacterial Resistance
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1749
Abstract: Macrolides, which bind in the protein exit tunnel of the bacterial ribosome, are one of the most prescribed classes of antibiotics.However, macrolide resistance caused by ribosomal modifications at base A2058 in segment 23S is a… read more here.
Keywords: macrolide; bacterial resistance; towards rational; resistance ... See more keywords
Macrolide-resistant Mycoplasma pneumoniae in South Korea: a strong association with M. pneumoniae type 1
Sign Up to like & getrecommendations! Published in 2019 at "Epidemiology and Infection"
DOI: 10.1017/s0950268819002000
Abstract: Abstract Mycoplasma pneumoniae is a main pathogen causing community-acquired pneumonia in children and young adults. Since the emergence of macrolide-resistant M. pneumoniae in the early 2000s in Japan, it has been increasingly reported worldwide as… read more here.
Keywords: macrolide; mycoplasma pneumoniae; pneumoniae; macrolide resistant ... See more keywords
Tetracycline- and Macrolide-Resistant Enterococcus Species Isolated from a Mink Farm in the United States.
Sign Up to like & getrecommendations! Published in 2022 at "Microbial drug resistance"
DOI: 10.1089/mdr.2021.0438
Abstract: Enterococcus species are a normal flora of animals and humans. However, life-threatening opportunistic infections can be caused by antimicrobial resistant strains. Fecal (n = 42) and feed (n = 8) samples were obtained from a mink farm and cultured… read more here.
Keywords: tetr; macrolide; enterococcus species; mink farm ... See more keywords
Investigation of Macrolide Resistance Genotypes of Pasteurella multocida Isolates from Cattle and Small Ruminants.
Sign Up to like & getrecommendations! Published in 2022 at "Microbial drug resistance"
DOI: 10.1089/mdr.2022.0010
Abstract: Macrolides are commonly used to control respiratory tract infections in ruminants, but the susceptibility of Pasteurella multocida strains has shown a decrease to macrolide antibiotics in the last decade. In this work we assessed the… read more here.
Keywords: macrolide; small ruminants; pasteurella multocida; macrolide resistance ... See more keywords
Men who have sex with men with Mycoplasma genitalium-positive nongonococcal urethritis are more likely to have macrolide resistant strains than men with only female partners: a prospective study.
Sign Up to like & getrecommendations! Published in 2019 at "Sexually Transmitted Diseases"
DOI: 10.1097/olq.0000000000001009
Abstract: BACKGROUND Mycoplasma genitalium was previously less common among men who have sex with men (MSM) compared with men with only female partners (MSW) in men with nongonococcal urethritis (NGU) in Sydney, Australia. We aimed to… read more here.
Keywords: macrolide; resistance; female partners; mycoplasma genitalium ... See more keywords
Assessment of Long-Term Macrolide Exposure on the Oropharyngeal Microbiome and Macrolide Resistance in Healthy Adults and Consequences for Onward Transmission of Resistance
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02246-21
Abstract: While the use of long-term macrolide therapy to prevent exacerbations in chronic respiratory diseases is widespread, its impact on the oropharyngeal microbiota and macrolide resistance and the potential for onward transmission of resistance to close… read more here.
Keywords: macrolide; long term; macrolide resistance; transmission ... See more keywords
A Rapid Screening Assay for Clarithromycin-Resistant Mycobacterium avium Complex Using Melting Curve Analysis with Nonfluorescent Labeled Probes
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.04326-22
Abstract: Since macrolide antibiotics such as clarithromycin or azithromycin are key drugs in multidrug therapy for Mycobacterium avium complex (MAC) lung diseases, the rapid detection of macrolide-resistant MAC strains has important implications for the treatment of… read more here.
Keywords: clarithromycin; macrolide; avium complex; mycobacterium avium ... See more keywords
O12.4 Prevalence of mycoplasma genitaliumand macrolide resistance in asymptomatic men who have sex with men (MSM) attending a sexual health centre
Sign Up to like & getrecommendations! Published in 2017 at "Sexually Transmitted Infections"
DOI: 10.1136/sextrans-2017-053264.69
Abstract: Introduction There are limited data on the prevalence of M. genitalium and macrolide resistance in asymptomatic MSM. Due to limited availability, testing for M. genitalium has generally been for symptomatic patients, such as men with… read more here.
Keywords: macrolide; prevalence; macrolide resistance; msm ... See more keywords
P664 In vitro evaluation of gepotidacin, an oral antimicrobial against multidrug-resistant mycoplasma genitalium
Sign Up to like & getrecommendations! Published in 2019 at "Sexually Transmitted Infections"
DOI: 10.1136/sextrans-2019-sti.731
Abstract: Background Mycoplasma genitalium has rapidly developed resistance to first-line azithromycin and second-line moxifloxacin. Third-line pristinamycin is difficult to source and only 80% effective. Consequently, there is an urgent need for alternative therapies, and to protect… read more here.
Keywords: macrolide; mycoplasma genitalium; dual resistant; resistance ... See more keywords
Development of Macrolide Resistance and Reinfection in Refractory Mycobacterium avium Complex Lung Disease
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Respiratory and Critical Care Medicine"
DOI: 10.1164/rccm.201802-0321oc
Abstract: Rationale: Patients with refractory Mycobacterium avium complex lung disease (MAC‐LD) undergo long‐term macrolide therapy, but macrolide resistance develops infrequently. Objectives: The aim of this study was to determine whether reinfection was a factor in the… read more here.
Keywords: macrolide; reinfection; treatment; mac ... See more keywords
Macrolide versus Non-Macrolide in Combination with Steroids for the Treatment of Lobar or Segmental Mycoplasma pneumoniae Pneumonia Unresponsive to Initial Macrolide Monotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11091233
Abstract: In the last few decades, macrolide-resistant Mycoplasma pneumoniae (MRMP) has been increasing in proportion. This study aimed to evaluate the treatment outcomes of children with lobar or segmental MP pneumonia unresponsive to the initial 3–5-day… read more here.
Keywords: macrolide steroid; macrolide; pneumonia; non macrolide ... See more keywords