Structural insights into context-specific inhibition of bacterial translation by macrolides
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DOI: 10.1038/s41467-025-64692-5
Abstract: The ribosome’s peptidyl transferase center (PTC) catalyzes peptide bond formation during protein synthesis and is targeted by many antibiotic classes. Remarkably, macrolides that bind in the peptide exit tunnel some ~10 Å away from the PTC… read more here.
Keywords: macrolides structural; arg lys; inhibition; context specific ... See more keywords