Analyzing the role of cancer-associated fibroblast activation on macrophage polarization.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13454
Abstract: Snail1 is a transcriptional factor required for cancer-associated fibroblast (CAF) activation, and mainly detected in CAFs in human tumors. In the mouse mammary tumor virus-polyoma middle tumor-antigen (MMTV-PyMT) model of murine mammary gland tumors, Snai1… read more here.
Keywords: cafs; polarization; cancer associated; tumor ... See more keywords
Gelatin‐Hyaluronan Click‐Crosslinked Cryogels Elucidate Human Macrophage Invasion Behavior
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202008400
Abstract: Hydrogel models of metastasis traditionally focus on the invasion of cancer cells; however, other cells in the tumor microenvironment that are associated with metastasis also have the ability to migrate. Macrophage phenotype plays a key… read more here.
Keywords: macrophage invasion; crosslinked cryogels; macrophage; invasion ... See more keywords
Supramolecular Macrophage‐Liposome Marriage for Cell‐Hitchhiking Delivery and Immunotherapy of Acute Pneumonia and Melanoma
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202102440
Abstract: As many diseases are related to inflammation, the inflammatory tropism of immune cells may bring cell‐hitchhikers directly to the disease tissues in a highly targeted manner. The current cell‐hitchhiking strategies rely on either cellular internalization… read more here.
Keywords: cell hitchhiking; acute pneumonia; delivery; macrophage ... See more keywords
Calcium–Zinc Phosphate Chemical Conversion Coating Facilitates the Osteointegration of Biodegradable Zinc Alloy Implants by Orchestrating Macrophage Phenotype
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202537
Abstract: Zinc (Zn) alloys provide a new generation for orthopedic applications due to their essential physiological effects and promising degradation properties. However, excessive release of Zn ions (Zn2+) during degradation and the severe inflammatory microenvironment are… read more here.
Keywords: phenotype; zinc; phosphate chemical; chemical conversion ... See more keywords
Antifibrotic Effects of Tetrahedral Framework Nucleic Acids by Inhibiting Macrophage Polarization and Macrophage–Myofibroblast Transition in Bladder Remodeling
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202203076
Abstract: Bladder outlet obstruction (BOO) is a prevalent condition arising from urethral stricture, posterior urethral valves, and benign prostatic hyperplasia. Long‐term obstruction can lead to bladder remodeling, which is characterized by inflammatory cell infiltration, detrusor hypertrophy,… read more here.
Keywords: antifibrotic effects; bladder; tetrahedral framework; boo ... See more keywords
A multi-function hydrogel-coating engineered implant for rescuing biofilm infection and boosting osseointegration by macrophage-related immunomodulation.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300722
Abstract: Incurable bacterial infections, impenetrable microbial biofilm and dysregulated immune microenvironments are among the most intractable threats for the treatment of implant-associated infections (IAIs). Innovative methodologies combined with reactive oxygen species (ROS) scavenging suppress the oxidative… read more here.
Keywords: biofilm; macrophage; hydrogel coating; infection ... See more keywords
CD146 Associates with Gp130 to Control a Macrophage Pro‐inflammatory Program That Regulates the Metabolic Response to Obesity
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DOI: 10.1002/advs.202103719
Abstract: The mechanism of obesity‐related metabolic dysfunction involves the development of systemic inflammation, largely mediated by macrophages. Switching of M1‐like adipose tissue macrophages (ATMs) to M2‐like ATMs, a population of macrophages associated with weight loss and… read more here.
Keywords: cd146; pro inflammatory; polarization; obesity ... See more keywords
Mouse Modeling Dissecting Macrophage–Breast Cancer Communication Uncovered Roles of PYK2 in Macrophage Recruitment and Breast Tumorigenesis
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DOI: 10.1002/advs.202105696
Abstract: Abstract Macrophage infiltration in mammary tumors is associated with enhanced tumor progression, metastasis, and poor clinical outcome, and considered as target for therapeutic intervention. By using different genetic mouse models, the authors show that ablation… read more here.
Keywords: breast; breast cancer; recruitment; tumor ... See more keywords
Single‐cell RNA Sequencing Identified Novel Nr4a1+ Ear2+ Anti‐Inflammatory Macrophage Phenotype under Myeloid‐TLR4 Dependent Regulation in Anti‐Glomerular Basement Membrane (GBM) Crescentic Glomerulonephritis (cGN)
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202200668
Abstract: Previously, this study demonstrates the critical role of myeloid specific TLR4 in macrophage‐mediated progressive renal injury in anti‐glomerular basement membrane (anti‐GBM) crescentic glomerulonephritis (cGN); however, the underlying mechanism remains largely unknown. In this study, single‐cell… read more here.
Keywords: cgn; myeloid tlr4; nr4a1 ear2; anti inflammatory ... See more keywords
A Meaningful Attempt: Applying Dielectric Barrier Discharge Plasma to Induce Polarization of Macrophages.
Sign Up to like & getrecommendations! Published in 2023 at "Bioelectromagnetics"
DOI: 10.1002/bem.22446
Abstract: Macrophage polarization plays an important role in many macrophage-related diseases. This study was designed to preliminarily explore the effects of dielectric barrier discharge (DBD) plasma on the polarization direction and cell activity of macrophages with… read more here.
Keywords: barrier discharge; dbd plasma; dielectric barrier; polarization ... See more keywords
Biology of macrophage fate decision: Implication in inflammatory disorders
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11854
Abstract: The activation of immune cells in response to stimuli present in their microenvironment is regulated by their metabolic profile. Unlike the signal transduction events, which overlap to a huge degree in diverse cellular processes, the… read more here.
Keywords: fate decision; macrophage fate; decision implication; macrophage ... See more keywords