Analyzing the role of cancer-associated fibroblast activation on macrophage polarization.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13454
Abstract: Snail1 is a transcriptional factor required for cancer-associated fibroblast (CAF) activation, and mainly detected in CAFs in human tumors. In the mouse mammary tumor virus-polyoma middle tumor-antigen (MMTV-PyMT) model of murine mammary gland tumors, Snai1… read more here.
Keywords: cafs; polarization; cancer associated; tumor ... See more keywords
Vortex Nanodiscs Functionalization to Overcome Macrophage Recognition for Efficient Theragnosis Applications
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Engineering Materials"
DOI: 10.1002/adem.202400369
Abstract: Biological barriers prevent nanotherapeutics successful accumulation at target cells, limiting diagnosis and treatment responses. Magnetic nanodiscs with a spin‐vortex ground state have shown great promise for magnetomechanical cancer cells annihilation and for neuronal stimulation, requiring… read more here.
Keywords: overcome macrophage; vortex nanodiscs; functionalization overcome; nanodiscs functionalization ... See more keywords
Gelatin‐Hyaluronan Click‐Crosslinked Cryogels Elucidate Human Macrophage Invasion Behavior
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202008400
Abstract: Hydrogel models of metastasis traditionally focus on the invasion of cancer cells; however, other cells in the tumor microenvironment that are associated with metastasis also have the ability to migrate. Macrophage phenotype plays a key… read more here.
Keywords: macrophage invasion; crosslinked cryogels; macrophage; invasion ... See more keywords
Supramolecular Macrophage‐Liposome Marriage for Cell‐Hitchhiking Delivery and Immunotherapy of Acute Pneumonia and Melanoma
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202102440
Abstract: As many diseases are related to inflammation, the inflammatory tropism of immune cells may bring cell‐hitchhikers directly to the disease tissues in a highly targeted manner. The current cell‐hitchhiking strategies rely on either cellular internalization… read more here.
Keywords: cell hitchhiking; acute pneumonia; delivery; macrophage ... See more keywords
A Zombie Macrophage‐Based “Trojan horse” Enhances the Effect of Efferocytosis Through Immune Regulation for Atherosclerosis Treatment
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202315034
Abstract: Various immune cell‐mediated drug delivery systems have been reported for precision medicine, but the proinflammatory differentiation of immunocyte vehicles can exacerbate disease progression, resulting in a formidable obstacle to efficacious pharmacotherapy. The progression of atherosclerosis… read more here.
Keywords: treatment; atherosclerosis; macrophage; trojan horse ... See more keywords
An MSR1‐Targeting Glycolipid Platform for Imaging the Changes of Phagocytic Macrophages in the Progression of Atherosclerotic Plaque
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202516172
Abstract: The progression of atherosclerosis (AS) plaque is marked by a shift in the main cell component of phagocytic macrophages from myeloid‐derived to vascular smooth muscle cell (VSMCs)‐derived macrophages. It remains a great challenge to identify… read more here.
Keywords: plaque; macrophage; glycolipid platform; msr1 targeting ... See more keywords
Calcium–Zinc Phosphate Chemical Conversion Coating Facilitates the Osteointegration of Biodegradable Zinc Alloy Implants by Orchestrating Macrophage Phenotype
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202537
Abstract: Zinc (Zn) alloys provide a new generation for orthopedic applications due to their essential physiological effects and promising degradation properties. However, excessive release of Zn ions (Zn2+) during degradation and the severe inflammatory microenvironment are… read more here.
Keywords: phenotype; zinc; phosphate chemical; chemical conversion ... See more keywords
Antifibrotic Effects of Tetrahedral Framework Nucleic Acids by Inhibiting Macrophage Polarization and Macrophage–Myofibroblast Transition in Bladder Remodeling
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202203076
Abstract: Bladder outlet obstruction (BOO) is a prevalent condition arising from urethral stricture, posterior urethral valves, and benign prostatic hyperplasia. Long‐term obstruction can lead to bladder remodeling, which is characterized by inflammatory cell infiltration, detrusor hypertrophy,… read more here.
Keywords: antifibrotic effects; bladder; tetrahedral framework; boo ... See more keywords
A multi-function hydrogel-coating engineered implant for rescuing biofilm infection and boosting osseointegration by macrophage-related immunomodulation.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300722
Abstract: Incurable bacterial infections, impenetrable microbial biofilm and dysregulated immune microenvironments are among the most intractable threats for the treatment of implant-associated infections (IAIs). Innovative methodologies combined with reactive oxygen species (ROS) scavenging suppress the oxidative… read more here.
Keywords: biofilm; macrophage; hydrogel coating; infection ... See more keywords
Ligand‐Selective Targeting of Macrophage Hydrogel Elicits Bone Immune‐Stem Cell Endogenous Self‐Healing Program to Promote Bone Regeneration
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202303851
Abstract: Targeting macrophages can facilitate the site‐specific repair of critical bone defects. Herein, a composite hydrogel, gelatin‐Bletilla striata polysaccharide‐mesoporous bioactive glass hydrogel (GBMgel), is constructed via the self‐assembly of mesoporous bioactive glass on polysaccharide structures, through… read more here.
Keywords: hydrogel; stem; macrophage; bone ... See more keywords
Electrospun Poly‐l‐Lactic Acid Membranes Promote M2 Macrophage Polarization by Regulating the PCK2/AMPK/mTOR Signaling Pathway
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202400481
Abstract: Electrospun membranes are widely used in tissue engineering. Regretfully, there is limited research on how its morphological characteristics precisely regulate macrophage activation and immune response. Therefore, electrospun poly‐l‐lactic acid (PLLA) membranes with different alignments (align… read more here.
Keywords: mtor signaling; macrophage; electrospun poly; macrophage polarization ... See more keywords