Modeling of an immune response: Queuing network analysis of the impact of zinc and cadmium on macrophage activation
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DOI: 10.1002/bit.27579
Abstract: Chronic obstructive pulmonary disease is characterized by progressive, irreversible airflow obstruction resulting from an abnormal inflammatory response to noxious gases and particles. Alveolar macrophages rely on the transcription factors, nuclear factor κB and mitogen‐activated protein… read more here.
Keywords: response; macrophage activation; zinc; model ... See more keywords
Evidence for dispensability of protein kinase R in host control of tuberculosis
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DOI: 10.1002/eji.201747180
Abstract: Genetic deficiency of protein kinase R (PKR) in mice was reported to enhance macrophage activation in vitro in response to interferon‐γ (IFNγ) and to reduce the burden of Mycobacterium tuberculosis (Mtb) in vivo (Wu et… read more here.
Keywords: pkr; macrophage activation; tuberculosis; protein kinase ... See more keywords
Macrophage activation syndrome due to Nocardia spp in a pediatric patient with cystic fibrosis
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DOI: 10.1002/ppul.24262
Abstract: Nocardia spp is a gram‐positive aerobic filamentous bacteria that causes pulmonary and systemic infections, especially in patients with immunosuppression or chronic lung diseases. It is rarely reported in children with cystic fibrosis. Macrophage activation syndrome… read more here.
Keywords: cystic fibrosis; activation syndrome; macrophage activation;
Role of Heparanase in Macrophage Activation.
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DOI: 10.1007/978-3-030-34521-1_17
Abstract: Macrophages represent one of the most diverse immunocyte populations, constantly shifting between various phenotypes/functional states. In addition to execution of vital functions in normal physiological conditions, macrophages represent a key contributing factor in the pathogenesis… read more here.
Keywords: heparanase macrophage; heparanase; macrophage activation; role heparanase ... See more keywords
Aloperine suppresses LPS-induced macrophage activation through inhibiting the TLR4/NF-κB pathway
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DOI: 10.1007/s00011-019-01313-0
Abstract: Objective The currently available anti-inflammatory drugs often cause diverse side effects with long-term use. Exploring anti-inflammatory drugs with better efficacy and lower toxicity presents an ongoing challenge. Aloperine is an alkaloid extracted from the leaves… read more here.
Keywords: aloperine suppresses; lps induced; macrophage activation; induced macrophage ... See more keywords
Adult-onset Still’s disease with macrophage activation syndrome diagnosed and treated based on cytokine profiling: a case-based review
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DOI: 10.1007/s00296-019-04446-x
Abstract: Adult-onset Still’s disease (AOSD) is a relatively rare systemic inflammatory disorder and is diagnosed using various sets of classification criteria, with the Yamaguchi criteria as the most widely used criteria. Herein, we present the case… read more here.
Keywords: onset still; cytokine; adult onset; macrophage activation ... See more keywords
A Personalized Diagnostic and Treatment Approach for Macrophage Activation Syndrome and Secondary Hemophagocytic Lymphohistiocytosis in Adults
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DOI: 10.1007/s10875-017-0439-x
Abstract: ObjectiveWe assessed the clinical features and outcomes based on therapeutic options adopted during hospital stay for adult patients with macrophage activation syndrome and secondary hemophagocytic lymphohistiocytosis (MAS/sHLH).MethodsWe conducted a retrospective chart review of all adult… read more here.
Keywords: adult; macrophage activation; treatment; mas shlh ... See more keywords
Autoinflammatory Diseases in Pediatric Dermatology-Part 2: Histiocytic, Macrophage Activation, and Vasculitis Syndromes.
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DOI: 10.1016/j.ad.2016.12.022
Abstract: The discovery of new autoinflammatory syndromes and novel mutations has advanced at breakneck speed in recent years. Part 2 of this review focuses on vasculitis syndromes and the group of histiocytic and macrophage activation syndromes.… read more here.
Keywords: part; dermatology; macrophage activation; vasculitis syndromes ... See more keywords
Prognostic factors of macrophage activation syndrome, at the time of diagnosis, in adult patients affected by autoimmune disease: Analysis of 41 cases collected in 2 rheumatologic centers.
Sign Up to like & getrecommendations! Published in 2017 at "Autoimmunity reviews"
DOI: 10.1016/j.autrev.2016.09.016
Abstract: Macrophage activation syndrome (MAS) is a rare, life-threatening disease in which early diagnosis and aggressive therapeutic strategy may improve the outcome. Due to its rarity, epidemiologic data are still lacking. Hyperferritinemia is frequently associated with… read more here.
Keywords: adult; macrophage activation; diagnosis; time diagnosis ... See more keywords
Clinical spectrum and therapeutic management of systemic lupus erythematosus-associated macrophage activation syndrome: A study of 103 episodes in 89 adult patients.
Sign Up to like & getrecommendations! Published in 2017 at "Autoimmunity reviews"
DOI: 10.1016/j.autrev.2017.05.010
Abstract: OBJECTIVES Macrophage activation syndrome (MAS) is a life-threatening hyperinflammatory syndrome that can occur during systemic lupus erythematosus (SLE). Data on MAS in adult SLE patients are very limited. The aim of this study is to… read more here.
Keywords: macrophage activation; study; 103 episodes; activation syndrome ... See more keywords
IGF1 Shapes Macrophage Activation in Response to Immunometabolic Challenge.
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DOI: 10.1016/j.celrep.2017.03.046
Abstract: In concert with their phagocytic activity, macrophages are thought to regulate the host immunometabolic responses primarily via their ability to produce specific cytokines and metabolites. Here, we show that IL-4-differentiated, M2-like macrophages secrete IGF1, a… read more here.
Keywords: shapes macrophage; challenge; macrophage activation; activation ... See more keywords