Iron oxide nanoparticles promote macrophage autophagy and inflammatory response through activation of toll-like Receptor-4 signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2019.02.026
Abstract: Nanoparticle-induced autophagy is crucial for its metabolism, cytotoxicity and therapy potency, but little is known about how the host immune system would respond to it. In this study, we demonstrated that two clinically used superparamagnetic… read more here.
Keywords: macrophage autophagy; iron oxide; oxide nanoparticles; promote macrophage ... See more keywords
Corticotropin releasing hormone promotes inflammatory bowel disease via inducing intestinal macrophage autophagy
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death Discovery"
DOI: 10.1038/s41420-021-00767-8
Abstract: Psychosocial stress is a vital factor contributing to the pathogenesis and progression of inflammatory bowel disease (IBD). The contribution of intestinal macrophage autophagy to the onset and development of IBD has been widely studied. Herein,… read more here.
Keywords: inflammatory bowel; autophagy; intestinal macrophage; ibd ... See more keywords
Macrophage autophagy protects against hepatocellular carcinogenesis in mice
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-98203-5
Abstract: Autophagy is a lysosomal degradation pathway of cellular components that regulates macrophage properties. Macrophages are critically involved in tumor growth, metastasis, angiogenesis and immune suppression. Here, we investigated whether macrophage autophagy may protect against hepatocellular… read more here.
Keywords: macrophage autophagy; expression; mice; macrophage ... See more keywords
Artemisinin attenuated atherosclerosis in high-fat diet-fed ApoE-/- mice by promoting macrophage autophagy via AMPK/mTOR/ULK1 pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000000794
Abstract: Artemisinin is an endoperoxide sesquiterpene lactone from Artemisia annua L with multiple beneficial effects, including anti-inflammation, anti-oxidant and vascular protection. Recent studies have found that inflammation along with autophagy deficiency in macrophages are the possible… read more here.
Keywords: macrophage; macrophage autophagy; artemisinin; mtor ulk1 ... See more keywords
CCL6 promotes M2 polarization and inhibits macrophage autophagy by activating PI3‐kinase/Akt signalling pathway during skin wound healing
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Dermatology"
DOI: 10.1111/exd.14718
Abstract: The transition of macrophages from the proinflammatory M1 to the anti‐inflammatory M2 phenotype is crucial during the wound healing process. In this study, we assess the role of chemokine (C‐C motif) ligand 6 (CCL6) in… read more here.
Keywords: pi3 kinase; wound healing; macrophage autophagy; ccl6 ... See more keywords
Progress in preclinical studies of macrophage autophagy in the regulation of ALI/ARDS
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.922702
Abstract: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a critical clinical syndrome with high morbidity and mortality that poses a major challenge in critical care medicine. The development of ALI/ARDS involves excessive inflammatory response,… read more here.
Keywords: progress preclinical; autophagy ali; macrophage autophagy; ali ards ... See more keywords
Macrophage autophagy in macrophage polarization, chronic inflammation and organ fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.946832
Abstract: As the essential regulators of organ fibrosis, macrophages undergo marked phenotypic and functional changes after organ injury. These changes in macrophage phenotype and function can result in maladaptive repair, causing chronic inflammation and the development… read more here.
Keywords: chronic inflammation; organ fibrosis; macrophage autophagy; fibrosis ... See more keywords