AZD6738 Attenuates LPS-Induced Corneal Inflammation and Fibrosis by Modulating Macrophage Function and Polarization
Sign Up to like & getrecommendations! Published in 2025 at "Inflammation"
DOI: 10.1007/s10753-025-02251-2
Abstract: This study aimed to evaluate the therapeutic potential of AZD6738, an ATR inhibitor, in LPS-induced bacterial keratitis (BK) by targeting macrophage function and polarization. A murine model of LPS-induced BK was established, with AZD6738 (100… read more here.
Keywords: macrophage function; macrophage; inflammation; lps induced ... See more keywords
Glioma cell-derived FGF20 suppresses macrophage function by activating β-catenin.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2021.110181
Abstract: Macrophages, which are the main regulators of the tumor-associated microenvironment, play a crucial role in the progression of various tumors. The anti-inflammatory role of β-catenin in macrophages has been extensively studied in recent years. However,… read more here.
Keywords: glioma; catenin; glioma cells; macrophage function ... See more keywords
Cystic fibrosis transmembrane conductance regulator (CFTR) modulators have differential effects on cystic fibrosis macrophage function
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35151-7
Abstract: Despite the addition of cystic fibrosis transmembrane conductance regulator (CFTR) modulators to the cystic fibrosis (CF) treatment regimen, patients with CF continue to suffer from chronic bacterial infections that lead to progressive respiratory morbidity. Host… read more here.
Keywords: ivacaftor; cystic fibrosis; macrophage function; macrophage ... See more keywords
Effects of lysosomal low-density lipoprotein oxidation by ferritin on macrophage function
Sign Up to like & getrecommendations! Published in 2022 at "Free Radical Research"
DOI: 10.1080/10715762.2022.2133703
Abstract: Abstract We have previously demonstrated that low-density lipoprotein (LDL) can be oxidized by iron in the lysosomes of macrophages. Some of the iron content of lysosomes might be delivered through autophagy of ferritin (the main… read more here.
Keywords: ferritin; oxidation; low density; macrophage function ... See more keywords
Innate sensing and cellular metabolism: role in fine tuning antiviral immune responses.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of leukocyte biology"
DOI: 10.1093/jleuko/qiac011
Abstract: Several studies over the last decade have identified intimate links between cellular metabolism and macrophage function. Metabolism has been shown to both drive and regulate macrophage function by producing bioenergetic and biosynthetic precursors as well… read more here.
Keywords: metabolism; immune responses; cellular metabolism; macrophage function ... See more keywords
The CaSR/TRPV4 coupling mediates pro‐inflammatory macrophage function
Sign Up to like & getrecommendations! Published in 2023 at "Acta Physiologica"
DOI: 10.1111/apha.13926
Abstract: Although calcium‐sensing receptor (CaSR) and transient receptor potential vanilloid 4 (TRPV4) channels are functionally expressed on macrophages, it is unclear if they work coordinately to mediate macrophage function. The present study investigates whether CaSR couples… read more here.
Keywords: casr; casr trpv4; macrophage function;
The Role of Zinc and Zinc Homeostasis in Macrophage Function
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Immunology Research"
DOI: 10.1155/2018/6872621
Abstract: Zinc has long been recognized as an essential trace element, playing roles in the growth and development of all living organisms. In recent decades, zinc homeostasis was also found to be important for the innate… read more here.
Keywords: zinc; macrophage function; zinc homeostasis; zinc zinc ... See more keywords
Abstract Th0043: In vivo CRISPR-Screening Identifies Fhl3 as a Potential Regulator of Macrophage Accumulation in Atherosclerotic Plaques
Sign Up to like & getrecommendations! Published in 2025 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atv.45.suppl_1.th0043
Abstract: Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death and disability worldwide. Recent clinical trials have shown that inflammation plays a critical role in ASCVD. Plaque inflammation is primarily driven by inflammatory macrophage accumulation… read more here.
Keywords: macrophage function; macrophage; vivo crispr; crispr ... See more keywords
Investigating macrophage function as a mechanism of resistance to daratumumab in relapsed refractory multiple myeloma patients.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.e20547
Abstract: e20547Background: Daratumumab (Dara), an anti-CD38 antibody, has a variety of Fc-dependent immune effector mechanisms of action including macrophage-mediated antibody-dependent cellular phagocytosi... read more here.
Keywords: function mechanism; investigating macrophage; macrophage function; macrophage ... See more keywords
Regulation of Intracellular Triiodothyronine Is Essential for Optimal Macrophage Function.
Sign Up to like & getrecommendations! Published in 2018 at "Endocrinology"
DOI: 10.1210/en.2018-00053
Abstract: Innate immune cells, including macrophages, have recently been identified as target cells for thyroid hormone. We hypothesized that optimal intracellular concentrations of the active thyroid hormone triiodothyronine (T3) are essential for proinflammatory macrophage function. T3… read more here.
Keywords: triiodothyronine essential; thyroid hormone; macrophage function; macrophage ... See more keywords
Innate Rhythms: Clocks at the Center of Monocyte and Macrophage Function
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.01743
Abstract: The circadian cycle allows organisms to track external time of day and predict/respond to changes in the external environment. In higher order organisms, circadian rhythmicity is a central feature of innate and adaptive immunity. We… read more here.
Keywords: rhythms clocks; innate rhythms; macrophage function; monocyte macrophage ... See more keywords