IL-1 beta-mediated macrophage-hepatocyte crosstalk upregulates hepcidin under physiological low oxygen levels
Sign Up to like & getrecommendations! Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2019.101209
Abstract: In mammals, the iron masterswitch hepcidin efficiently controls iron recycling by the macrophage-liver axis but the exact interplay between macrophages and hepatocytes remains poorly understood. We here study hepcidin response during macrophage differentiation as well… read more here.
Keywords: oxygen; hepcidin; macrophage; hepatocyte crosstalk ... See more keywords
Inflammatory macrophage to hepatocyte signals can be prevented by extracellular vesicle reprogramming
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cell Science"
DOI: 10.1242/jcs.260691
Abstract: ABSTRACT Macrophage-derived extracellular vesicles (EVs) play key roles in intercellular communication. Within the liver, they have been linked to several inflammatory diseases including nonalcoholic fatty liver disease (NAFLD). In this study, we found that inflammatory… read more here.
Keywords: signals prevented; hepatocyte signals; inflammatory; macrophage hepatocyte ... See more keywords