Macrophage 12(S)-HETE Enhances Angiotensin II–Induced Contraction by a BLT2 (Leukotriene B4 Type-2 Receptor) and TP (Thromboxane Receptor)-Mediated Mechanism in Murine Arteries
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DOI: 10.1161/hypertensionaha.121.17824
Abstract: Supplemental Digital Content is available in the text. 12/15-LO (12/15-lipoxygenase), encoded by Alox15 gene, metabolizes arachidonic acid to 12(S)-HETE (12-hydroxyeicosatetraenoic acid). Macrophages are the major source of 12/15-LO among immune cells, and 12/15-LO plays a… read more here.
Keywords: macrophage hete; hypertension; receptor; angiotensin induced ... See more keywords