A population pharmacokinetic-pharmacodynamic model of navtemadlin, its glucuronide metabolite (M1) and serum macrophage inhibitory cykokine-1 (MIC-1)
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DOI: 10.1080/00498254.2022.2114116
Abstract: Abstract Navtemadlin is a potent, selective, orally available inhibitor of murine double minute 2 that restores p53 activity to induce apoptosis in TP53 wild-type malignancies. Using richly sampled pharmacokinetic (PK) and pharmacodynamic (PD) data from… read more here.
Keywords: serum macrophage; pharmacokinetic pharmacodynamic; macrophage inhibitory; model ... See more keywords