Glucocorticoids coordinate macrophage metabolism through the regulation of the tricarboxylic acid cycle
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2021.101424
Abstract: Objectives Glucocorticoids (GCs) are one of the most widely prescribed anti-inflammatory drugs. By acting through their cognate receptor, the glucocorticoid receptor (GR), GCs downregulate the expression of pro-inflammatory genes and upregulate the expression of anti-inflammatory… read more here.
Keywords: macrophage metabolism; cycle; tricarboxylic acid; metabolism ... See more keywords
Macrophage metabolism in the intestine is compartment specific and regulated by the microbiota
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13461
Abstract: Intestinal macrophages play a vital role in the maintenance of gut homeostasis through signals derived from the microbiota. We previously demonstrated that microbial‐derived metabolites can shape the metabolic functions of macrophages. Here, we show that… read more here.
Keywords: macrophage metabolism; macrophage; metabolic functions; compartment specific ... See more keywords
Aminooxyacetic acid attenuates post‐infarct cardiac dysfunction by balancing macrophage polarization through modulating macrophage metabolism in mice
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14972
Abstract: Excessive activation of pro‐inflammatory M1 macrophages following acute myocardial infarction (MI) aggravates adverse cardiac remodelling and heart dysfunction. There are two break points in the tricarboxylic acid cycle of M1 macrophages, and aspartate‐arginosuccinate shunt compensates… read more here.
Keywords: macrophage polarization; acid; macrophage; macrophage metabolism ... See more keywords
Optical changes in THP-1 macrophage metabolism in response to pro- and anti-inflammatory stimuli reported by label-free two-photon imaging
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomedical Optics"
DOI: 10.1117/1.jbo.25.1.014512
Abstract: Abstract. Temporal changes in macrophage metabolism are likely crucial to their role in inflammatory diseases. Label-free two-photon excited fluorescence (TPEF) and fluorescence lifetime imaging microscopy are well suited to track dynamic changes in macrophage metabolism.… read more here.
Keywords: inflammatory; label free; macrophage metabolism; anti inflammatory ... See more keywords
Inflammation by way of macrophage metabolism
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.aan2691
Abstract: IL-10 controls macrophage inflammatory function by reprogramming metabolism Although inflammation is an essential component of immunity, an excessive response can lead to tissue damage and autoimmune pathologies. In most cases, this is avoided with parallel,… read more here.
Keywords: metabolism; inflammation way; inflammation; macrophage metabolism ... See more keywords
Human alveolar macrophage metabolism is compromised during Mycobacterium tuberculosis infection
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1044592
Abstract: Pulmonary macrophages have two distinct ontogenies: long-lived embryonically-seeded alveolar macrophages (AM) and bone marrow-derived macrophages (BMDM). Here, we show that after infection with a virulent strain of Mycobacterium tuberculosis (H37Rv), primary murine AM exhibit a… read more here.
Keywords: mycobacterium tuberculosis; human alveolar; infection; macrophage metabolism ... See more keywords
The helminth derived peptide FhHDM-1 redirects macrophage metabolism towards glutaminolysis to regulate the pro-inflammatory response
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1018076
Abstract: We have previously identified an immune modulating peptide, termed FhHDM-1, within the secretions of the liver fluke, Fasciola hepatica, which is sufficiently potent to prevent the progression of type 1 diabetes and multiple sclerosis in… read more here.
Keywords: metabolism; derived peptide; helminth derived; macrophage metabolism ... See more keywords
Reprogramming Macrophage Metabolism and its Effect on NLRP3 Inflammasome Activation in Sepsis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.917818
Abstract: Sepsis, the most common life-threatening multi-organ dysfunction syndrome secondary to infection, lacks specific therapeutic strategy due to the limited understanding of underlying mechanisms. It is currently believed that inflammasomes play critical roles in the development… read more here.
Keywords: sepsis; macrophage metabolism; reprogramming macrophage; activation ... See more keywords
Targeting immunometabolism during cardiorenal injury: roles of conventional and alternative macrophage metabolic fuels
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2023.1139296
Abstract: Macrophages play critical roles in mediating and resolving tissue injury as well as tissue remodeling during cardiorenal disease. Altered immunometabolism, particularly macrophage metabolism, is a critical underlying mechanism of immune dysfunction and inflammation, particularly in… read more here.
Keywords: immunometabolism; macrophage metabolism; injury; macrophage ... See more keywords