A local application of mesenchymal stem cells and cyclosporine A attenuates immune response by a switch in macrophage phenotype
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.2044
Abstract: The immunosuppressive effects of systemically administered mesenchymal stem cells (MSCs) and immunosuppressive drugs have been well documented. We analysed the mechanisms underlying the therapeutic effect of MSCs applied locally in combination with non‐specific immunosuppression in… read more here.
Keywords: macrophage phenotype; mscs; immune response; stem cells ... See more keywords
The Histone Methyltransferase Setdb2 Modulates Macrophage Phenotype and Uric Acid Production in Diabetic Wound Repair.
Sign Up to like & getrecommendations! Published in 2019 at "Immunity"
DOI: 10.1016/j.immuni.2019.06.015
Abstract: Macrophage plasticity is critical for normal tissue repair to ensure transition from the inflammatory to the proliferative phase of healing. We examined macrophages isolated from wounds of patients afflicted with diabetes and of healthy controls… read more here.
Keywords: setdb2; macrophage phenotype; uric acid; wound ... See more keywords
Polarized cytokine release from airway epithelium differentially influences macrophage phenotype.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular immunology"
DOI: 10.1016/j.molimm.2021.01.029
Abstract: Epithelial cells and macrophages represent two major cell populations in the lung. They reside in physical proximity and are influenced by inhaled substances, microbial- and host-derived factors, as well as by crosstalk between each other.… read more here.
Keywords: macrophage phenotype; cytokine release; apical basolateral; expression ... See more keywords
Reprogramming Macrophage Phenotype Using a Reactive Oxygen Species-Responsive Liposome Delivery System for Inflammation Microenvironment Remodeling and Osteoarthritis Treatment.
Sign Up to like & getrecommendations! Published in 2025 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.4c19160
Abstract: The progression of osteoarthritis (OA) is closely linked to synovial inflammation caused by an imbalance between M1 and M2 macrophages. To tackle this problem, we developed a liposome responsive to reactive oxygen species (ROS), modified… read more here.
Keywords: macrophage phenotype; delivery system; inflammation; oxygen species ... See more keywords
Destructive fibrotic teamwork: how both microenvironment stiffness and profibrotic interleukin 13 impair alveolar macrophage phenotype and function.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm00828a
Abstract: The pulmonary fibrotic microenvironment is characterized by increased stiffness of lung tissue and enhanced secretion of profibrotic soluble cues contributing to a feedback loop that leads to dysregulated wound healing and lung failure. Pinpointing the… read more here.
Keywords: macrophage phenotype; microenvironment; stiffness; microenvironment stiffness ... See more keywords
Low-Dose Decitabine Assists Human Umbilical Cord-Derived Mesenchymal Stem Cells in Protecting β Cells via the Modulation of the Macrophage Phenotype in Type 2 Diabetic Mice
Sign Up to like & getrecommendations! Published in 2020 at "Stem Cells International"
DOI: 10.1155/2020/4689798
Abstract: Background Progressive β-cell dysfunction, a major characteristic of type 2 diabetes (T2D), is closely related to the infiltration of inflammatory macrophages within islets. Mesenchymal stem cells (MSCs) have been identified to alleviate β-cell dysfunction by… read more here.
Keywords: macrophage phenotype; stem cells; group; macrophage ... See more keywords
Abstract 3810: Ovarian tumor-induced changes in macrophage phenotype are associated with tumor metastasis
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-3810
Abstract: Background: Ovarian cancer (OVCA) differs from other gynecologic malignancies in its dissemination pattern where the tumor migrates in a diffuse intrapelvic and -abdominal manner. OVCA also triggers a variety of cellular and/or humoral immune responses… read more here.
Keywords: macrophage phenotype; induced changes; tumor induced; ovarian tumor ... See more keywords
Abstract 146: Studying the effect of compressive solid stress on macrophage phenotype and function in the context of glioblastoma
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-146
Abstract: Glioblastoma (GBM) is one of the most aggressive forms of brain cancer, with an overall survival of less than two years. One barrier to therapeutic efficacy is the extremely immunosuppressive GBM tumor microenvironment (TME). Myeloid… read more here.
Keywords: macrophage phenotype; stress; tumor; solid stress ... See more keywords
Glia maturation factor-γ regulates murine macrophage iron metabolism and M2 polarization through mitochondrial ROS.
Sign Up to like & getrecommendations! Published in 2019 at "Blood advances"
DOI: 10.1182/bloodadvances.2018026070
Abstract: In macrophages, cellular iron metabolism status is tightly integrated with macrophage phenotype and associated with mitochondrial function. However, how molecular events regulate mitochondrial activity to integrate regulation of iron metabolism and macrophage phenotype remains unclear.… read more here.
Keywords: macrophage phenotype; iron; iron metabolism;
A Study on the Role of Wip1 in Renal Fibrosis by Modulating Macrophage Phenotype.
Sign Up to like & getrecommendations! Published in 2022 at "Archives of medical research"
DOI: 10.21203/rs.3.rs-1222762/v1
Abstract: BACKGROUND Renal fibrosis is the result of chronic kidney diseases, the exploration of the pathogenesis of renal fibrosis and the development of effective treatment methods have become major challenges. AIMS To investigate the effect of… read more here.
Keywords: wip1; macrophage phenotype; role; renal fibrosis ... See more keywords
Macrophages: The Good, the Bad, and the Gluttony
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.708186
Abstract: Macrophages are dynamic cells that play critical roles in the induction and resolution of sterile inflammation. In this review, we will compile and interpret recent findings on the plasticity of macrophages and how these cells… read more here.
Keywords: macrophage phenotype; inflammation; macrophage; allergic asthma ... See more keywords