Transcriptional control of macrophage polarisation in type 2 diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in Immunopathology"
DOI: 10.1007/s00281-019-00748-1
Abstract: Type-2 diabetes (T2D) is considered today as an inflammatory disease. Inflammatory processes in T2D are orchestrated by macrophage activation in different organs. Macrophages undergo classical M1 pro-inflammatory or alternative M2 anti-inflammatory activation in response to… read more here.
Keywords: transcriptional control; macrophage polarisation; type diabetes; macrophage ... See more keywords
Role of macrophage polarisation in skin wound healing.
Sign Up to like & getrecommendations! Published in 2023 at "International wound journal"
DOI: 10.1111/iwj.14119
Abstract: Skin wound healing is a complex pathophysiological change that is driven by macrophages and their secreted related factors. Depending on the stimuli, macrophages can be polarised into two subtypes of macrophages with completely different phenotypes… read more here.
Keywords: role; skin wound; macrophage polarisation; wound healing ... See more keywords
ZIP8 Regulates Inflammation and Macrophage Polarisation in Intervertebral Disc Degeneration via the Wnt/β‐Catenin Pathway
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.70431
Abstract: One main cause of persistent back discomfort is intervertebral disc degeneration (IDD), with inflammation and extracellular matrix (ECM) degradation playing critical roles. This study investigates the role of ZIP8, a zinc transporter, in IDD pathogenesis,… read more here.
Keywords: disc degeneration; wnt catenin; zip8; macrophage polarisation ... See more keywords
Serine Promotes Inflammatory Macrophage Polarisation in Periodontitis via NAD+ Signalling.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of clinical periodontology"
DOI: 10.1111/jcpe.70058
Abstract: AIM To investigate the role of serine in modulating macrophage polarisation and periodontal inflammation. MATERIALS AND METHODS Saliva samples were obtained from periodontitis patients, healthy individuals and periodontitis remission patients for salivary metabolomics analysis. C57BL/6J… read more here.
Keywords: inflammatory macrophage; macrophage polarisation; periodontitis; serine ... See more keywords
Ageing-Related Macrophage Polarisation in the Trigeminal Ganglion Enhances Incisional Intraoral Pain.
Sign Up to like & getrecommendations! Published in 2024 at "Oral diseases"
DOI: 10.1111/odi.15165
Abstract: OBJECTIVE Although macrophage polarisation in the trigeminal ganglion (TG) is crucial in orofacial pain hypersensitivity, the effect of ageing-related changes and their involvement in intra-oral nociception remains unclear. We assessed the effect of ageing-related macrophage… read more here.
Keywords: pain; ccl2; macrophage; ageing related ... See more keywords
THU0056 14–3–3 is a molecular switch regulating macrophage polarisation in inflammatory arthritis
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.4729
Abstract: Background Functional heterogeneity is a hallmark of macrophages, which can classified into 2 major phenotypes with opposite role in inflammation termed M1 (inflammatory or classically activated) macrophages and M2 (alternatively activated) macrophages. In addition, M1-M2… read more here.
Keywords: polarisation; macrophage polarisation; inflammatory arthritis; pgrn ... See more keywords
In vivo single‐cell transcriptomics reveal Klebsiella pneumoniae skews lung macrophages to promote infection
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202216888
Abstract: The strategies deployed by antibiotic‐resistant bacteria to counteract host defences are poorly understood. Here, we elucidate a novel host–pathogen interaction resulting in skewing lung macrophage polarisation by the human pathogen Klebsiella pneumoniae. We identify interstitial… read more here.
Keywords: klebsiella pneumoniae; klebsiella; lung macrophages; lung ... See more keywords