Instructing Human Macrophage Polarization by Stiffness and Glycosaminoglycan Functionalization in 3D Collagen Networks
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DOI: 10.1002/adhm.201600967
Abstract: Dynamic alterations of composition and mechanics of the extracellular matrix are suggested to modulate cellular behavior including plasticity of macrophages (MPhs) during wound healing. In this study, engineered 3D fibrillar matrices based on naturally occurring… read more here.
Keywords: wound healing; stiffness; instructing human; macrophage polarization ... See more keywords
Metformin regulates macrophage polarization via the Shh signaling pathway to improve pulmonary vascular development in bronchopulmonary dysplasia
Sign Up to like & getrecommendations! Published in 2021 at "IUBMB Life"
DOI: 10.1002/iub.2588
Abstract: Metformin has potential anti‐inflammatory properties and accelerates wound healing by enhancing vascular development. In this study, we aimed to investigate the effects of metformin on pulmonary vascular development and the underlying mechanism. Newborn mice were… read more here.
Keywords: macrophage polarization; vascular development; polarization; pulmonary vascular ... See more keywords
Proanthocyanidins suppress NLRP3 inflammasome and M1 macrophage polarization to alleviate severe acute pancreatitis in mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23242
Abstract: The role of reactive oxygen species (ROS) is crucial for the pathogenesis of acute pancreatitis (AP). Proanthocyanidins (PAs) have been confirmed to exert antioxidant activity. Our study aimed to determine whether PAs alleviated SAP via… read more here.
Keywords: macrophage polarization; acute pancreatitis; nlrp3 inflammasome; mice ... See more keywords
Macrophage M1/M2 polarization dynamically adapts to changes in microenvironment and modulates alveolar bone remodeling after dental implantation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.1ma0121-001r
Abstract: As one of the first arriving immune cells after dental implantation, Mϕs own the abilities to polarize into to a spectrum of diverse phenotypes, from “classically activated” M1 Mϕs to “alternatively activated” M2 Mϕs. Herein,… read more here.
Keywords: dental implantation; polarization dynamically; dynamically adapts; macrophage polarization ... See more keywords
Periodontal ligament stem cells promote polarization of M2 macrophages.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of leukocyte biology"
DOI: 10.1002/jlb.1ma1220-853rr
Abstract: Macrophages are widely distributed in a variety of tissues, and the different state of macrophages polarization is closely related to the occurrence, development, and prognosis of inflammation, including periodontitis, a chronic inflammatory disease leading to… read more here.
Keywords: pdlscs; stem cells; macrophage polarization; polarization ... See more keywords
Mitochondrial dysfunction caused by SIRT3 inhibition drives proinflammatory macrophage polarization in obesity
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DOI: 10.1002/oby.23707
Abstract: Metabolic reprogramming is a main feature of proinflammatory macrophage polarization, a process that leads to inflammation in dysfunctional adipose tissue. Therefore, the study aim was to explore whether sirtuin 3 (SIRT3), a mitochondrial deacetylase, participates… read more here.
Keywords: obesity mitochondrial; proinflammatory macrophage; macrophage polarization;
Andrographolide suppresses breast cancer progression by modulating tumor‐associated macrophage polarization through the Wnt/β‐catenin pathway
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DOI: 10.1002/ptr.7578
Abstract: Andrographolide(ADE) has been demonstrated to inhibit tumor growth through direct cytotoxicity on tumor cells. However, its potential activity on tumor microenvironment (TME) remains unclear. Tumor‐associated macrophages (TAMs), composed mainly of M2 macrophages, are the key… read more here.
Keywords: macrophage polarization; tumor associated; polarization; tumor ... See more keywords
Chiral Ruthenium Nanozymes with Self-Cascade Reaction Driven the NO Generation Induced Macrophage M1 Polarization Realizing the Lung Cancer "Cocktail Therapy".
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DOI: 10.1002/smll.202207823
Abstract: Macrophages as the main cause of cancer immunosuppression, how to effectively induce macrophage M1 polarization remain the major challenge in lung cancer therapy. Herein, inspired by endogenous reactions, a strategy is proposed to coactivate macrophage… read more here.
Keywords: lung cancer; macrophage polarization; cocktail therapy; therapy ... See more keywords
Exosomal lncRNA HMMR-AS1 mediates macrophage polarization through miR-147a/ARID3A axis under hypoxia and affects the progression of hepatocellular carcinoma.
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DOI: 10.1002/tox.23489
Abstract: BACKGROUND At present, the role of lncRNA in different kinds of tumors has been widely reported, but its role with hypoxic environment and macrophage polarization is still unclear. Therefore, this study tried to clarify the… read more here.
Keywords: hmmr; lncrna hmmr; macrophage polarization; hmmr as1 ... See more keywords
hUC‐MSCs exosomal miR‐451 alleviated acute lung injury by modulating macrophage M2 polarization via regulating MIF‐PI3K‐AKT signaling pathway
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DOI: 10.1002/tox.23639
Abstract: In the previous study, we have proved that exosomal miR‐451 from human umbilical cord mesenchymal stem cells (hUC‐MSCs) attenuated burn‐induced acute lung injury (ALI). However, the mechanism of exosomal miR‐451 in ALI remains unclear. Therefore,… read more here.
Keywords: mir 451; macrophage polarization; huc mscs; exosomal mir ... See more keywords
Naringenin facilitates M2 macrophage polarization after myocardial ischemia–reperfusion by promoting nuclear translocation of transcription factor EB and inhibiting the NLRP3 inflammasome pathway
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DOI: 10.1002/tox.23774
Abstract: Myocardial ischemia–reperfusion injury (MIRI) remains an unsolved puzzle in medical circles. Naringenin (NAR) is a flavonoid with cardioprotective potential. The purpose of this article was to discuss the protective mechanism of NAR in MIRI by… read more here.
Keywords: macrophage polarization; inflammasome pathway; nuclear translocation; polarization ... See more keywords