Photocurrent‐Directed Immunoregulation Accelerates Osseointegration through Activating Calcium Influx in Macrophages
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DOI: 10.1002/adfm.202406095
Abstract: Early osteoimmune microenvironment disorder at the interface between bone and implant can lead to implant loosening, which prolongs patient convalescence, exacerbates postoperative complications, and potentially results in implant failure. The timely regulation of macrophages primarily… read more here.
Keywords: macrophage polarization; calcium; calcium influx; osteoimmune microenvironment ... See more keywords
Instructing Human Macrophage Polarization by Stiffness and Glycosaminoglycan Functionalization in 3D Collagen Networks
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DOI: 10.1002/adhm.201600967
Abstract: Dynamic alterations of composition and mechanics of the extracellular matrix are suggested to modulate cellular behavior including plasticity of macrophages (MPhs) during wound healing. In this study, engineered 3D fibrillar matrices based on naturally occurring… read more here.
Keywords: wound healing; stiffness; instructing human; macrophage polarization ... See more keywords
Electrospun Poly‐l‐Lactic Acid Membranes Promote M2 Macrophage Polarization by Regulating the PCK2/AMPK/mTOR Signaling Pathway
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DOI: 10.1002/adhm.202400481
Abstract: Electrospun membranes are widely used in tissue engineering. Regretfully, there is limited research on how its morphological characteristics precisely regulate macrophage activation and immune response. Therefore, electrospun poly‐l‐lactic acid (PLLA) membranes with different alignments (align… read more here.
Keywords: mtor signaling; macrophage; electrospun poly; macrophage polarization ... See more keywords
JPT2 Affects Trophoblast Functions and Macrophage Polarization and Metabolism, and Acts as a Potential Therapeutic Target for Recurrent Spontaneous Abortion
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DOI: 10.1002/advs.202306359
Abstract: Recurrent spontaneous abortion (RSA) is a pregnancy‐related condition with complex etiology. Trophoblast dysfunction and abnormal macrophage polarization and metabolism are associated with RSA; however, the underlying mechanisms remain unknown. Jupiter microtubule‐associated homolog 2 (JPT2) is… read more here.
Keywords: spontaneous abortion; recurrent spontaneous; jpt2; macrophage polarization ... See more keywords
The Thyroid Hormone Analog GC‐1 Mitigates Acute Lung Injury by Inhibiting M1 Macrophage Polarization
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DOI: 10.1002/advs.202401931
Abstract: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a life‐threatening condition with a high mortality rate of ≈40%. Thyroid hormones (THs) play crucial roles in maintaining homeostasis of the cellular microenvironment under stress. The… read more here.
Keywords: injury; lung injury; macrophage polarization;
Citrullination of NF‐κB p65 by PAD2 as a Novel Therapeutic Target for Modulating Macrophage Polarization in Acute Lung Injury
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DOI: 10.1002/advs.202413253
Abstract: Mediating protein citrullination, peptidyl arginine deiminase 2 (PAD2) has recently been reported to influence macrophage phenotypes. However, the mechanisms of PAD2 on macrophage function in Pseudomonas aeruginosa (PA)‐induced acute lung injury syndrome (ALI) remains unclear.… read more here.
Keywords: macrophage polarization; citrullination; lung injury; acute lung ... See more keywords
Calhm6 Governs Macrophage Polarization Through Chp1-Camk4-Creb1 Axis and Ectosomal Delivery in Inflammatory Responses.
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DOI: 10.1002/advs.202502395
Abstract: Macrophage plasticity, critical for immune response, is often dysregulated in various infectious and inflammatory diseases. While ion channels have been implicated in immune cell modulation, how they influence macrophage polarization remains poorly understood. Here, it… read more here.
Keywords: chp1 camk4; calhm6; macrophage polarization; inflammatory ... See more keywords
Human iPSCs Derived MSCs‐Secreted Exosomes Modulate Senescent Nucleus Pulposus Cells Induced Macrophage Polarization via Metabolic Reprogramming to Mitigate Intervertebral Disc Degeneration
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DOI: 10.1002/advs.202504347
Abstract: Intervertebral disc degeneration (IDD) is a leading cause of discogenic lower back pain, yet the crosstalk between macrophage polarization and nucleus pulposus (NP) cell senescence in IDD progression remains poorly understood. Emerging therapies using human… read more here.
Keywords: disc degeneration; intervertebral disc; nucleus pulposus; macrophage polarization ... See more keywords
UBD‐mediated glycolytic reprogramming promotes M2 macrophage polarization in ovarian cancer immune evasion
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cell Communication and Signaling"
DOI: 10.1002/ccs3.70034
Abstract: Ovarian cancer (OC) is one of the most common malignant tumors in women, with immunotherapy resistance (ITR) being a major challenge. Glycolytic metabolic reprogramming has been shown to play a crucial role in the tumor… read more here.
Keywords: polarization; immune evasion; ovarian cancer; macrophage polarization ... See more keywords
Monitoring Macrophage Polarization in Infectious Disease, Lesson From SARS‐CoV‐2 Infection
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DOI: 10.1002/ird3.70006
Abstract: The concept of macrophage polarization has been largely used in human diseases to define a typology of activation of myeloid cells reminiscent of lymphocyte functional subsets. In COVID‐19, several studies have investigated myeloid compartment dysregulation… read more here.
Keywords: sars cov; monocytes macrophages; macrophage polarization; activation ... See more keywords
Metformin regulates macrophage polarization via the Shh signaling pathway to improve pulmonary vascular development in bronchopulmonary dysplasia
Sign Up to like & getrecommendations! Published in 2021 at "IUBMB Life"
DOI: 10.1002/iub.2588
Abstract: Metformin has potential anti‐inflammatory properties and accelerates wound healing by enhancing vascular development. In this study, we aimed to investigate the effects of metformin on pulmonary vascular development and the underlying mechanism. Newborn mice were… read more here.
Keywords: macrophage polarization; vascular development; polarization; pulmonary vascular ... See more keywords