Salidroside alleviates ulcerative colitis via inhibiting macrophage pyroptosis and repairing the dysbacteriosis‐associated Th17/Treg imbalance
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DOI: 10.1002/ptr.7636
Abstract: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by flora disequilibrium and mucosal immunity disorder. Here, we report that salidroside effectively restricts experimental colitis from two aspects of intestinal macrophage pyroptosis and dysbacteriosis‐derived… read more here.
Keywords: macrophage pyroptosis; th17 treg; pyroptosis; colitis ... See more keywords
IFN regulatory Factor-1 induced macrophage pyroptosis by modulating m6A modification of circ_0029589 in patients with acute coronary syndrome.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106800
Abstract: BACKGROUND Pyroptosis is identified as a novel form of inflammatory programmed cell death and has been recently found to be closely related to atherosclerosis (AS). We found that IFN regulatory factor-1(IRF-1) effectively promotes macrophage pyroptosis… read more here.
Keywords: hsa circ; circ 0029589; macrophage pyroptosis;
Sphingosine-1-phosphate Receptor 2 Signaling Promotes Caspase-11–dependent Macrophage Pyroptosis and Worsens Escherichia coli Sepsis Outcome
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DOI: 10.1097/aln.0000000000002196
Abstract: What We Already Know about This TopicNo molecular-targeted treatments for sepsis have proved successful in humans. The role of sphingosine-1-phosphate receptor 2 (S1PR2) signaling in sepsis is uncertain. What This Article Tells Us That Is… read more here.
Keywords: sepsis; caspase; pyroptosis; macrophage pyroptosis ... See more keywords
Preconditioning with rHMGB1 ameliorates lung ischemia–reperfusion injury by inhibiting alveolar macrophage pyroptosis via the Keap1/Nrf2/HO-1 signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-020-02467-w
Abstract: Background Lung ischemia–reperfusion injury (LIRI) is a complex pathophysiological process that can lead to poor patient outcomes. Inflammasome-dependent macrophage pyroptosis contributes to organ damage caused by ischemia/reperfusion injury. Oxidative stress and antioxidant enzymes also play… read more here.
Keywords: reperfusion; injury; macrophage pyroptosis; rhmgb1 ... See more keywords
Characterization of Cathepsin B in Mediating Silica Nanoparticle-Induced Macrophage Pyroptosis via an NLRP3-Dependent Manner
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DOI: 10.2147/jir.s371536
Abstract: Introduction Silica nanoparticles (SiNPs) are one of the most widely used inorganic nanomaterials, and exposure to SiNP has been demonstrated to induce pulmonary inflammation, primarily promoted by the NLRP3-mediated macrophage pyroptosis. However, mechanisms underlying the… read more here.
Keywords: macrophage pyroptosis; ctsb; expression nlrp3; pyroptosis ... See more keywords
Acute Silica Exposure Triggers Pulmonary Inflammation Through Macrophage Pyroptosis: An Experimental Simulation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.874459
Abstract: Silica is an essential substrate of various materials, and inhaling silica induces pulmonary diseases potentially associated with macrophage pyroptosis. Utilizing silica of micro- and nano- sizes, we explored the role of macrophage pyroptosis in silica-induced… read more here.
Keywords: pulmonary inflammation; macrophage pyroptosis; silica; macrophage ... See more keywords