Reduced calcification and osteogenic features in advanced atherosclerotic plaques of mice with macrophage-specific loss of TRPC3.
Sign Up to like & getrecommendations! Published in 2018 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2017.12.025
Abstract: BACKGROUND AND AIMS Recent in vitro studies have showed that in macrophages, deletion of the non-selective Ca2+-permeable channel TRPC3 impairs expression of the osteogenic protein BMP-2. The pathophysiological relevance of this effect in atherosclerotic plaque calcification… read more here.
Keywords: ldlr mice; trpc3; mice macrophage; calcification ... See more keywords
Macrophage-specific EphB2 Deficiency Mitigates Nonalcoholic Steatohepatitis-fibrosis in Mice
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733240
Abstract: Background & Aims: Emerging evidence suggests that the receptor tyrosine kinase EphB2 regulates tissue inflammation and fibrosis. However, its contribution to non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD or NASH) remains largely unknown; thus, we aimed… read more here.
Keywords: specific ephb2; macrophage specific; physiology; mice ... See more keywords
Macrophage-Specific IGF-1 Overexpression Reduces CXCL12 Chemokine Levels and Suppresses Atherosclerotic Burden in Apoe-Deficient Mice
Sign Up to like & getrecommendations! Published in 2021 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.121.316090
Abstract: Supplemental Digital Content is available in the text. Objective: IGF-1 (insulin-like growth factor 1) exerts pleiotropic effects including promotion of cellular growth, differentiation, survival, and anabolism. We have shown that systemic IGF-1 administration reduced atherosclerosis… read more here.
Keywords: macrophage; macrophage specific; atherosclerotic burden; igf overexpression ... See more keywords
Identification of the macrophage‐specific promoter signature in FANTOM5 mouse embryo developmental time course data
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Leukocyte Biology"
DOI: 10.1189/jlb.1a0417-150rr
Abstract: The FANTOM5 consortium used cap analysis of gene expression (CAGE) to analyze the time course of gene expression over development from 11 days postcoitum (dpc) to adult in 16 developing organs and the whole body… read more here.
Keywords: time course; time; expression; macrophage ... See more keywords
Role of Hepatocyte- and Macrophage-Specific PPARγ in Hepatotoxicity Induced by Diethylhexyl Phthalate in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Health Perspectives"
DOI: 10.1289/ehp9373
Abstract: Background: Phthalates may disturb metabolic homeostasis in the liver by interfering with the peroxisome proliferator-activated receptors (PPARs). However, the role of hepatic macrophages in the lipid metabolic dysregulation induced by diethylhexyl phthalate (DEHP) remains unclear.… read more here.
Keywords: phthalate; ppar; specific ppar; macrophage specific ... See more keywords
Macrophage-Specific Connexin 43 Knockout Protects Mice from Obesity-Induced Inflammation and Metabolic Dysfunction
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.925971
Abstract: Adipose tissue macrophages are a major immune cell type contributing to homeostatic maintenance and pathological adipose tissue remodeling. However, the mechanisms underlying macrophage recruitment and polarization in adipose tissue during obesity remain poorly understood. Previous… read more here.
Keywords: hfd induced; macrophage specific; adipose tissue; tissue ... See more keywords
Deletion of Macrophage-Specific Glycogen Synthase Kinase (GSK)-3α Promotes Atherosclerotic Regression in Ldlr−/− Mice
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23169293
Abstract: Recent evidence from our laboratory suggests that impeding ER stress–GSK3α/β signaling attenuates the progression and development of atherosclerosis in mouse model systems. The objective of this study was to determine if the tissue-specific genetic ablation… read more here.
Keywords: regression; ldlr mice; macrophage specific; gsk3 ... See more keywords
Macrophage-Specific, Mafb-Deficient Mice Showed Delayed Skin Wound Healing
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23169346
Abstract: Macrophages play essential roles throughout the wound repair process. Nevertheless, mechanisms regulating the process are poorly understood. MAFB is specifically expressed in the macrophages in hematopoietic tissue and is vital to homeostatic function. Comparison of… read more here.
Keywords: wound healing; mafb; skin wound; macrophage specific ... See more keywords
Inhibition of Macrophage-Specific CHIT1 as an Approach to Treat Airway Remodeling in Severe Asthma
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054719
Abstract: Chitotriosidase (CHIT1) is an enzyme produced by macrophages that regulates their differentiation and polarization. Lung macrophages have been implicated in asthma development; therefore, we asked whether pharmacological inhibition of macrophage-specific CHIT1 would have beneficial effects… read more here.
Keywords: chit1; macrophage specific; airway remodeling; inhibition macrophage ... See more keywords
PLGA Based Nanospheres as a Potent Macrophage-Specific Drug Delivery System
Sign Up to like & getrecommendations! Published in 2021 at "Nanomaterials"
DOI: 10.3390/nano11030749
Abstract: Macrophages possess an innate ability to scavenge heterogenous objects from the systemic circulation and to regulate inflammatory diseases in various organs via cytokine production. That makes them attractive targets for nanomedicine-based therapeutic approaches to inflammatory… read more here.
Keywords: drug delivery; plga; macrophage specific; macrophage ... See more keywords