Macrophage-targeting gene silencing orchestrates myocardial microenvironment remodeling toward the anti-inflammatory treatment of ischemia-reperfusion (IR) injury
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DOI: 10.1016/j.bioactmat.2022.01.026
Abstract: Ischemia-reperfusion (IR) injury represents a major cause of myocardial dysfunction after infarction and thrombolytic therapy, and it is closely related to the free radical explosion and overwhelming inflammatory responses. Herein, macrophage-targeting nanocomplexes (NCs) are developed… read more here.
Keywords: myocardial microenvironment; macrophage targeting; reperfusion injury; ischemia reperfusion ... See more keywords
Macrophage-targeting oligopeptides from Mortierella alpina
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DOI: 10.1039/d2sc00860b
Abstract: The realm of natural products of early diverging fungi such as Mortierella species is largely unexplored. Herein, the nonribosomal peptide synthetase (NRPS) MalA catalysing the biosynthesis of the surface-active biosurfactants, malpinins, has been identified and… read more here.
Keywords: mortierella alpina; mortierella; targeting oligopeptides; specificity ... See more keywords
Macrophage targeting: opening new possibilities for cancer immunotherapy
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DOI: 10.1111/imm.12976
Abstract: Tumour‐infiltrating immune cells regulate tumour development and progression either negatively or positively. For example, cytotoxic lymphocytes (CTL) such as CD8+ T and natural killer (NK) cells can recognize and eliminate cancer cells, and thereby restrict… read more here.
Keywords: tumour infiltrating; macrophage targeting; ctl; cancer ... See more keywords