Development of Octreotide-Loaded Chitosan and Heparin Nanoparticles: Evaluation of Surface Modification Effect on Physicochemical Properties and Macrophage Uptake.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2019.05.002
Abstract: Octreotide (OCT) is a therapeutic peptide which is administered for the treatment of acromegaly. The purpose of this study was to design a new polyethylene glycol (PEG)-conjugated nanoparticle (PEG-NP) to overcome the short half-life and… read more here.
Keywords: heparin; macrophage uptake; peg nps; nps peg ... See more keywords
Polyglycerol Grafting Shields Nanoparticle from Protein Corona Formation to Avoid Macrophage Uptake.
Sign Up to like & getrecommendations! Published in 2020 at "ACS nano"
DOI: 10.1021/acsnano.0c02289
Abstract: Upon contact with biofluids, proteins are quickly adsorbed onto nanoparticle (NP) surface to form a protein corona, which initiates the opsonization and facilitates the rapid clearance of NP by macrophage uptake. Although polyethylene glycol (PEG)… read more here.
Keywords: macrophage uptake; polyglycerol grafting; corona formation; spectroscopy ... See more keywords
Effects of Surface-Bound Collagen-Mimetic Peptides on Macrophage Uptake and Immunomodulation
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2020.00747
Abstract: The interaction between collagen/collagen-like peptides and the commonly expressed immune cell receptor LAIR-1 (leukocyte-associated immunoglobulin-like receptor-1) regulates and directs immune responses throughout the body. Understanding and designing these interactions within the context of biomaterials could… read more here.
Keywords: collagen; surface bound; macrophage uptake; lair ... See more keywords