Macrophages promote cartilage regeneration in a time‐ and phenotype‐dependent manner
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DOI: 10.1002/jcp.30694
Abstract: Immune regulation of osteochondral defect regeneration has not yet been rigorously characterized. Although macrophages have been demonstrated to regulate the regeneration process in various tissues, their direct contribution to cartilage regeneration remains to be investigated,… read more here.
Keywords: regeneration; promote cartilage; cartilage; cartilage regeneration ... See more keywords
Macrophages Promote Resistance to Checkpoint Inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-nb2017-081
Abstract: A study in mice suggests that macrophages produce resistance to checkpoint inhibitors by removing anti-PD-1 antibodies from T cells. Fcγ receptors on macrophages bind to the Fc domain on the antibodies. Blocking this interaction with… read more here.
Keywords: macrophages promote; promote resistance; resistance checkpoint; checkpoint inhibitors ... See more keywords
Subcapsular Sinus Macrophages Promote Melanoma Metastasis to the Sentinel Lymph Nodes via an IL1α–STAT3 Axis
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-22-0225
Abstract: The authors show that subcapsular sinus macrophages promote aggressiveness of metastatic melanoma cells by releasing IL1α, which upregulates STAT3 signaling in the tumor. Blocking IL1α could synergize with STAT3 inhibitors in treating metastatic melanoma. read more here.
Keywords: promote melanoma; subcapsular sinus; il1; macrophages promote ... See more keywords
Macrophages Promote Aortic Valve Cell Calcification and Alter STAT3 Splicing
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DOI: 10.1161/atvbaha.120.314360
Abstract: Objective: Macrophages have been described in calcific aortic valve disease, but it is unclear if they promote or counteract calcification. We aimed to determine how macrophages are involved in cal... read more here.
Keywords: valve cell; valve; calcification; macrophages promote ... See more keywords
Macrophages promote the progression of premalignant mammary lesions to invasive cancer.
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DOI: 10.18632/oncotarget.14913
Abstract: Breast cancer initiation, progression and metastasis rely on a complex interplay between tumor cells and their surrounding microenvironment. Infiltrating immune cells, including macrophages, promote mammary tumor progression and metastasis; however, less is known about the… read more here.
Keywords: progression metastasis; macrophages promote; early stage; cancer ... See more keywords
Epigenetically altered macrophages promote development of diabetes-associated atherosclerosis
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DOI: 10.3389/fimmu.2023.1196704
Abstract: Background Atherosclerosis (AS) risk is elevated in diabetic patients, but the underlying mechanism such as involvement of epigenetic control of foam macrophages remains unclear. We have previously shown the importance of immune regulation on endothelial… read more here.
Keywords: promote development; development diabetes; altered macrophages; epigenetically altered ... See more keywords