Nlrp3 inflammasome activation in macrophages suffices for inducing autoinflammation in mice
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DOI: 10.15252/embr.202154339
Abstract: Cryopyrin‐associated periodic syndromes (CAPS) are a spectrum of autoinflammatory disorders caused by gain‐of‐function NLRP3 mutant proteins that form hyperactive inflammasomes leading to overproduction of the pro‐inflammatory cytokines IL‐1β and IL‐18. Expressing the murine gain‐of‐function Nlrp3A350V… read more here.
Keywords: activation macrophages; macrophages suffices; autoinflammation; inflammasome activation ... See more keywords