DFMO and 5-azacytidine increase M1 macrophages in the tumor microenvironment of murine ovarian cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-4018
Abstract: Although ovarian cancer has a low incidence rate, it remains the most deadly gynecologic malignancy. Previous work has demonstrated that the DNMTi 5-Azacytidine (AZA) activates type I interferon signaling to increase IFNγ+ T cells and… read more here.
Keywords: ovarian cancer; tumor microenvironment; cancer; dfmo ... See more keywords
Abstract 4497: Delineating the effects of different levels of nitric oxide produced by "M1" stimulated macrophages on tumor rejection and response to therapy
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4497
Abstract: Nitric Oxide (NO) was historically known to be immunosuppressive in cancers by inhibiting T-cell function and endothelial activation. This is relevant however only in the aberrant, dysfunctional tumor vasculature. Recently, local low dose irradiation was… read more here.
Keywords: different levels; stimulated macrophages; tumor rejection; nitric oxide ... See more keywords
Expression of combinatorial immunoglobulins in macrophages in the tumor microenvironment
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DOI: 10.1371/journal.pone.0204108
Abstract: Recent evidence indicates the presence of macrophage subpopulations that express the TCRαβ in chronic inflammatory diseases such as tuberculosis and atherosclerosis and in the tumor microenvironment. Here, we demonstrate that a second subpopulation of macrophages… read more here.
Keywords: heavy light; tumor microenvironment; expression combinatorial; macrophages tumor ... See more keywords
Bacteria and macrophages in the tumor microenvironment
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2023.1115556
Abstract: Cancer and microbial infections are significant worldwide health challenges. Numerous studies have demonstrated that bacteria may contribute to the emergence of cancer. In this review, we assemble bacterial species discovered in various cancers to describe… read more here.
Keywords: macrophages tumor; bacteria macrophages; cancer; tumor microenvironment ... See more keywords
Small Tweaks, Major Changes: Post-Translational Modifications That Occur within M2 Macrophages in the Tumor Microenvironment
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DOI: 10.3390/cancers14225532
Abstract: Simple Summary Featuring functional diversity and plasticity, M2 macrophages have been typecasting as villain player in tumor microenvironment, propelling the growth and metastases of tumor cells and being closely related with shorter survival. Good things… read more here.
Keywords: macrophages tumor; review; post translational; within macrophages ... See more keywords
Role of macrophages in tumor progression and therapy (Review)
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DOI: 10.3892/ijo.2022.5347
Abstract: The number and phenotype of macrophages are closely related to tumor growth and prognosis. Macrophages are recruited to (and polarized at) the tumor site thereby promoting tumor growth, stimulating tumor angiogenesis, facilitating tumor cell migration,… read more here.
Keywords: tumor progression; macrophages tumor; role macrophages; tumor ... See more keywords