Tumor‐Associated Macrophages Write the Script of Cancer Obesity Paradox
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DOI: 10.1002/bies.202400264
Abstract: Obesity paradoxically advances cancer progression while enhancing certain immunotherapies, like anti‐PD‐1/PD‐L1. Bader et al. discovered that obesity‐driven factors increase PD‐1 on tumor‐associated macrophages (TAMs), suppressing anti‐tumor responses. Remarkably, anti‐PD‐1 therapy reverses this metabolic dysfunction, boosting… read more here.
Keywords: cancer; obesity; tumor associated; macrophages write ... See more keywords