Biomimetic Nanovaccines Potentiating Dendritic Cell Internalization via CXCR4‐Mediated Macropinocytosis
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202064
Abstract: Although targeted delivery of nanoparticulate vaccines to dendritic cells (DCs) holds tremendous potential, it still faces insufficient internalization and endosome degradation via the receptor‐mediated endocytosis pathway. Inspired by the advantages of CXC‐chemokine receptor type 4… read more here.
Keywords: biomimetic nanovaccines; internalization; mediated macropinocytosis; macropinocytosis ... See more keywords
Klf10 favors Mycobacterium tuberculosis survival by impairing IFN‐γ production and preventing macrophages reprograming to macropinocytosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4ma0422-288r
Abstract: Mycobacterium tuberculosis has developed diverse mechanisms to survive inside phagocytic cells, such as macrophages. Phagocytosis is a key process in eliminating invading pathogens; thus, M. tuberculosis efficiently disrupts phagosome maturation to ensure infection. However, inflammatory… read more here.
Keywords: tuberculosis survival; mycobacterium tuberculosis; klf10; tuberculosis ... See more keywords
Engineering ApoE3-incorporated biomimetic nanoparticle for efficient vaccine delivery to dendritic cells via macropinocytosis to enhance cancer immunotherapy.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.119795
Abstract: Efficient delivery of vaccines to dendritic cells (DCs) is critical for inducing sufficient immune response and realizing effective cancer immunotherapy. In the past decade, researchers have spent tremendous effort in delivering vaccines by using nanoparticles.… read more here.
Keywords: macropinocytosis; dendritic cells; cancer immunotherapy; apoe3 ... See more keywords
Dual blockade of macropinocytosis and asparagine bioavailability shows synergistic anti-tumor effects on KRAS-mutant colorectal cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.09.023
Abstract: Mutations of KRAS gene are found in various types of cancer, including colorectal cancer (CRC). Despite intense efforts, no pharmacological approaches are expected to be effective against KRAS-mutant cancers. Macropinocytosis is an evolutionarily conserved actin-dependent… read more here.
Keywords: macropinocytosis; asparagine; kras mutant; crc ... See more keywords
Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer cell"
DOI: 10.1016/j.ccell.2021.02.016
Abstract: Many cancers, including pancreatic ductal adenocarcinoma (PDAC), depend on autophagy-mediated scavenging and recycling of intracellular macromolecules, suggesting that autophagy blockade should cause tumor starvation and regression. However, until now autophagy-inhibiting monotherapies have not demonstrated potent… read more here.
Keywords: macropinocytosis; cells escape; inhibition; autophagy ... See more keywords
EGFR-Pak Signaling Selectively Regulates Glutamine Deprivation-Induced Macropinocytosis.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental cell"
DOI: 10.1016/j.devcel.2019.05.043
Abstract: Macropinocytosis has emerged as an important nutrient-scavenging pathway that supports tumor cell fitness. By internalizing extracellular protein and targeting it for lysosomal degradation, this endocytic pathway functions as an amino acid supply route, permitting tumor… read more here.
Keywords: egfr pak; macropinocytosis; pak signaling; signaling selectively ... See more keywords
Phellodendrine chloride suppresses proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2019.01.060
Abstract: ABSTRACT Despite the massive efforts to develop the treatment of pancreatic cancers, no effective application exhibits satisfactory clinical outcome. Macropinocytosis plays a critical role for continuous proliferation of pancreatic ductal adenocarcinoma (PDAC). In this study,… read more here.
Keywords: macropinocytosis; pancreatic cancer; cancer cells; cells inhibition ... See more keywords
Characterization of PGua4, a Guanidinium-Rich Peptoid that Delivers IgGs to the Cytosol via Macropinocytosis.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00783
Abstract: To investigate the structure-cellular penetration relationship of guanidinium-rich transporters (GRTs), we previously designed PGua4, a five-amino acid peptoid containing a conformationally restricted pattern of eight guanidines, which showed high cell-penetrating abilities and low cell toxicity.… read more here.
Keywords: characterization pgua4; peptoid; macropinocytosis; guanidinium rich ... See more keywords
Gold Nanoparticles Inhibit Macropinocytosis by Decreasing KRAS Activation.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.3c00920
Abstract: The RAS-transformed cells utilize macropinocytosis to acquire amino acids to support their uncontrolled growth. However, targeting RAS to inhibit macropinocytosis remains a challenge. Here, we report that gold nanoparticles (GNP) inhibit macropinocytosis by decreasing KRAS… read more here.
Keywords: inhibit macropinocytosis; macropinocytosis decreasing; gold nanoparticles; kras activation ... See more keywords
BMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-08533-2
Abstract: Retrograde BMP trans-synaptic signaling is essential for synaptic development. Despite the importance of endocytosis-regulated BMP receptor (BMPR) control of this developmental signaling, the mechanism remains unknown. Here, we provide evidence that Abelson interactor (Abi), a… read more here.
Keywords: bmp; bmp receptor; macropinocytosis; development ... See more keywords
Infectious pancreatic necrosis virus enters CHSE-214 cells via macropinocytosis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-03036-w
Abstract: Infectious pancreatic necrosis virus (IPNV) is a non-enveloped virus belonging to the Birnaviridae family. IPNV produces an acute disease in salmon fingerlings, with high mortality rates and persistent infection in survivors. Although there are reports… read more here.
Keywords: infectious pancreatic; pancreatic necrosis; necrosis virus; macropinocytosis ... See more keywords