The Pinx1 Gene Downregulates Telomerase and Inhibits Proliferation of CD133+ Cancer Stem Cells Isolated from a Nasopharyngeal Carcinoma Cell Line by Regulating Trfs and Mad1/C-Myc/p53 Pathways
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000492878
Abstract: Background/Aims: Cancer stem cells (CSCs) are important factors for the continuous growth, recurrence, and metastasis of malignant tumors. They are responsible for the ineffectiveness of traditional radiotherapy and chemotherapy toward malignant tumors. Currently, stem cells… read more here.
Keywords: cscs; cd133; proliferation; p53 ... See more keywords
Molecular mechanism of Mad1 kinetochore targeting by phosphorylated Bub1
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DOI: 10.15252/embr.202052242
Abstract: Abstract During metaphase, in response to improper kinetochore‐microtubule attachments, the spindle assembly checkpoint (SAC) activates the mitotic checkpoint complex (MCC), an inhibitor of the anaphase‐promoting complex/cyclosome (APC/C). This process is orchestrated by the kinase Mps1,… read more here.
Keywords: bub1; mad1 kinetochore; mad1; phosphorylated bub1 ... See more keywords