Molecular mechanism of Mad1 kinetochore targeting by phosphorylated Bub1
Sign Up to like & getrecommendations! Published in 2021 at "EMBO Reports"
DOI: 10.15252/embr.202052242
Abstract: Abstract During metaphase, in response to improper kinetochore‐microtubule attachments, the spindle assembly checkpoint (SAC) activates the mitotic checkpoint complex (MCC), an inhibitor of the anaphase‐promoting complex/cyclosome (APC/C). This process is orchestrated by the kinase Mps1,… read more here.
Keywords: bub1; mad1 kinetochore; mad1; phosphorylated bub1 ... See more keywords
MAD1: Kinetochore Receptors and Catalytic Mechanisms
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2018.00051
Abstract: The mitotic checkpoint monitors kinetochore-microtubule attachment, delays anaphase onset and prevents aneuploidy when unattached or tensionless kinetochores are present in cells. Mitotic arrest deficiency 1 (MAD1) is one of the evolutionarily conserved core mitotic checkpoint… read more here.
Keywords: kinetochore receptors; mad1 kinetochore; receptors catalytic; catalytic mechanisms ... See more keywords