Identification of a Sgo2-Dependent but Mad2-Independent Pathway Controlling Anaphase Onset in Fission Yeast
Sign Up to like & getrecommendations! Published in 2017 at "Cell Reports"
DOI: 10.1016/j.celrep.2017.01.032
Abstract: Summary The onset of anaphase is triggered by activation of the anaphase-promoting complex/cyclosome (APC/C) following silencing of the spindle assembly checkpoint (SAC). APC/C triggers ubiquitination of Securin and Cyclin B, which leads to loss of… read more here.
Keywords: anaphase; mad2 independent; sgo2 dependent; mad2 ... See more keywords
Basis of catalytic assembly of the mitotic checkpoint complex
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature21384
Abstract: In mitosis, for each daughter cell to inherit an accurate copy of the genome from the mother cell, sister chromatids in the mother cell must attach to microtubules emanating from opposite poles of the mitotic… read more here.
Keywords: mcc; conversion; sac; mad2 ... See more keywords
Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/s41586-018-0281-1
Abstract: The maintenance of genome stability during mitosis is coordinated by the spindle assembly checkpoint (SAC) through its effector the mitotic checkpoint complex (MCC), an inhibitor of the anaphase-promoting complex (APC/C, also known as the cyclosome)1,2.… read more here.
Keywords: p31comet; mcc; atpase trip13; trip13 ... See more keywords
Mad2 promotes Cyclin B2 recruitment to the kinetochore for guiding accurate mitotic checkpoint
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DOI: 10.15252/embr.202154171
Abstract: Accurate mitotic progression relies on the dynamic phosphorylation of multiple substrates by key mitotic kinases. Cyclin‐dependent kinase 1 is a master kinase that coordinates mitotic progression and requires its regulatory subunit Cyclin B to ensure… read more here.
Keywords: mad2 promotes; mad2; checkpoint; accurate mitotic ... See more keywords
The Mad2-Binding Protein p31comet as a potential target for human cancer therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Current cancer drug targets"
DOI: 10.2174/1568009621666210129095726
Abstract: The spindle assembly checkpoint (SAC) is a surveillance mechanism that prevents mitotic exit at the metaphase-to-anaphase transition until all chromosomes have established correct bipolar attachment to spindle microtubules. Activation of SAC relies on the assembly… read more here.
Keywords: mad2 binding; protein p31comet; p31comet potential; mad2 ... See more keywords
Phosphorylation of MAD2 at Ser195 Promotes Spindle Checkpoint Defects and Sensitizes Cancer Cells to Radiotherapy in ATM Deficient Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.817831
Abstract: The spindle assembly checkpoint (SAC) is a critical monitoring device in mitosis for the maintenance of genomic stability. Specifically, the SAC complex comprises several factors, including Mad1, Mad2, and Bub1. Ataxia-telangiectasia mutated (ATM) kinase, the… read more here.
Keywords: phosphorylation mad2; atm deficient; phosphorylation; deficient cells ... See more keywords