Human MAdCAM-1 antibodies as targeted immune modulators
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-26517-9
Abstract: Inflammatory bowel disease (IBD) is a highly prevalent condition characterized by chronic inflammation present along the gastrointestinal (GI) tract. Mitigation of symptoms is critical to the quality of life of patients. Targeting Mucosal Addressin-Cell Adhesion… read more here.
Keywords: madcam; madcam antibodies; targeted immune; human madcam ... See more keywords
MAdCAM-1-Mediated Intestinal Lymphocyte Homing Is Critical for the Development of Active Experimental Autoimmune Encephalomyelitis
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.00903
Abstract: Lymphocyte homing into the intestine is mediated by binding of leukocytes to mucosal addressin cell adhesion molecule 1 (MAdCAM-1), expressed on endothelial cells. Currently, the immune system of the gut is considered a major modulator… read more here.
Keywords: autoimmune encephalomyelitis; experimental autoimmune; madcam; lymphocyte homing ... See more keywords
Force-Regulated Calcium Signaling of Lymphoid Cell RPMI 8226 Mediated by Integrin α4β7/MAdCAM-1 in Flow
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13040587
Abstract: MAdCAM-1 binds to integrin α4β7, which mediates the rolling and arrest of circulating lymphocytes upon the vascular endothelia during lymphocytic homing. The calcium response by adhered lymphocytes is a critical event for lymphocyte activation and… read more here.
Keywords: rpmi 8226; calcium; calcium signaling; integrin ... See more keywords