Madecassic acid analogues with a five-membered A-ring and their cytotoxic activity.
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DOI: 10.1080/14786419.2024.2427811
Abstract: The structural modification of madecassic acid focused on the contraction of the six-membered A-ring to a five-membered ring, combined with the dehydration of 6-OH to form a new double bond and formation of the esterification… read more here.
Keywords: cytotoxic activity; membered ring; madecassic acid;
Madecassic Acid—A New Scaffold for Highly Cytotoxic Agents
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DOI: 10.3390/ijms23084362
Abstract: Due to their manifold biological activities, natural products such as triterpenoids have advanced to represent excellent leading structures for the development of new drugs. For this reason, we focused on the syntheses and cytotoxic evaluation… read more here.
Keywords: scaffold highly; cytotoxicity; madecassic acid; highly cytotoxic ... See more keywords
The dual functions of the pentacyclic triterpenoid madecassic acid in ameliorating doxorubicin-induced cardiotoxicity and enhancing the antitumor efficacy of doxorubicin
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DOI: 10.7150/ijbs.97418
Abstract: Doxorubicin (DOX) is an anthracycline that has excellent anticancer effects during tumor chemotherapy, but it can cause cardiotoxic effects and its clinical use has been limited. Therefore, finding new drugs or methods to prevent or… read more here.
Keywords: functions pentacyclic; madecassic acid; pentacyclic triterpenoid; cardiotoxicity enhancing ... See more keywords