Clearance of Maedi-visna infection in a longitudinal study of naturally infected rams is associated with homozygosity for the TMEM154 resistance allele
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Microbiology"
DOI: 10.1099/jmm.0.001506
Abstract: Maedi-visna (MV) is a lentiviral disease of sheep responsible for severe production losses in affected flocks. There are no vaccination or treatment options with control reliant on test and cull strategies. The most common diagnostic… read more here.
Keywords: naturally infected; maedi visna; infection; resistance ... See more keywords
Structural basis for recruitment of host CypA and E3 ubiquitin ligase by maedi-visna virus Vif
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.add3422
Abstract: Lentiviral Vif molecules target the host antiviral APOBEC3 proteins for destruction in cellular ubiquitin-proteasome pathways. Different lentiviral Vifs have evolved to use the same canonical E3 ubiquitin ligase complexes, along with distinct noncanonical host cofactors… read more here.
Keywords: ubiquitin ligase; maedi visna; vif; ligase ... See more keywords