The Mafb cleft‐associated variant H131Q is not required for palatogenesis in the mouse
Sign Up to like & getrecommendations! Published in 2021 at "Developmental Dynamics"
DOI: 10.1002/dvdy.327
Abstract: Orofacial clefts (OFCs) are common birth defects with complex etiology. Genome wide association studies for OFC have identified SNPs in and near MAFB. MAFB is a transcription factor critical for structural development of digits, kidneys,… read more here.
Keywords: mafb; mafb cleft; cleft associated; h131q ... See more keywords
MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1
Sign Up to like & getrecommendations! Published in 2017 at "Nature Medicine"
DOI: 10.1038/nm.4312
Abstract: Damage-associated molecular patterns (DAMPs) trigger sterile inflammation after tissue injury, but the mechanisms underlying the resolution of inflammation remain unclear. In this study, we demonstrate that common DAMPs, such as high-mobility-group box 1 (HMGB1), peroxiredoxins… read more here.
Keywords: mafb; ischemic stroke; inflammation; clearance ... See more keywords
Radiation inducible MafB gene is required for thymic regeneration
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-89836-7
Abstract: The thymus facilitates mature T cell production by providing a suitable stromal microenvironment. This microenvironment is impaired by radiation and aging which lead to immune system disturbances known as thymic involution. Young adult thymus shows… read more here.
Keywords: mafb; thymus; thymic regeneration; radiation inducible ... See more keywords
Repression of Mafb promotes foreskin fibroblast proliferation through upregulation of CDK2, cyclin E and PCNA
Sign Up to like & getrecommendations! Published in 2022 at "Andrologia"
DOI: 10.1111/and.14411
Abstract: Mafb plays a significant role in the development and differentiation of various organs, tissues and cells. Nevertheless, its role in the control of external genital cell proliferation and function in the mechanism of hypospadias remains… read more here.
Keywords: pcna; cdk2; proliferation; mafb ... See more keywords
Ectopic expression of the transcription factor MafB in basal keratinocytes induces hyperproliferation and perturbs epidermal homeostasis
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Dermatology"
DOI: 10.1111/exd.13364
Abstract: Mammalian epidermis is composed of four morphologically and functionally distinct layers of keratinocytes. The innermost basal layer consists of proliferating self‐renewing keratinocytes, which also undergo asymmetric cell division to differentiate into postmitotic suprabasal cells throughout… read more here.
Keywords: mafb; transcription; basal keratinocytes; epidermal homeostasis ... See more keywords
MafB Maintains β-Cell Identity under MafA-Deficient Conditions
Sign Up to like & getrecommendations! Published in 2022 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00541-21
Abstract: The transcription factor MafB plays an essential role in β-cell differentiation during the embryonic stage in rodents. Although MafB disappears from β-cells after birth, it has been reported that MafB can be evoked in β-cells… read more here.
Keywords: adult mice; cell; mafb; cell identity ... See more keywords
MAFB is dispensable for the fetal testis morphogenesis and the maintenance of spermatogenesis in adult mice
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0190800
Abstract: The transcription factor MAFB is an important regulator of the development and differentiation of various organs and tissues. Previous studies have shown that MAFB is expressed in embryonic and adult mouse testes and is expected… read more here.
Keywords: mafb; spermatogenesis; adult; cko mice ... See more keywords
MAFB mediates the therapeutic effect of sleeve gastrectomy for obese diabetes mellitus by activation of FXR expression
Sign Up to like & getrecommendations! Published in 2018 at "Brazilian Journal of Medical and Biological Research"
DOI: 10.1590/1414-431x20187312
Abstract: Farnesoid X receptor (FXR) and related pathways are involved in the therapeutic effect of sleeve gastrectomy for overweight or obese patients with diabetes mellitus. This study aimed to investigate the mechanism of FXR expression regulation… read more here.
Keywords: mafb; fxr; sleeve gastrectomy; expression ... See more keywords
MAFB and MAF Transcription Factors as Macrophage Checkpoints for COVID-19 Severity
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.603507
Abstract: Defective IFN production and exacerbated inflammatory and pro-fibrotic responses are hallmarks of SARS-CoV-2 infection in severe COVID-19. Based on these hallmarks, and considering the pivotal role of macrophages in COVID-19 pathogenesis, we hypothesize that the… read more here.
Keywords: mafb; mafb maf; severity; transcription factors ... See more keywords
Transcription Factor MafB Suppresses Type I Interferon Production by CD14+ Monocytes in Patients With Chronic Hepatitis C
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2019.01814
Abstract: Transcription factor MafB regulates differentiation and activity of monocytes/macrophage and is associated with the development of atherosclerosis and cancers. However, the role of MafB in modulation of CD14+ monocytes in chronic viral hepatitis was not… read more here.
Keywords: mafb; ifn; cd14 monocytes; chronic hepatitis ... See more keywords
Transcription factor MAFB controls type I and II interferon response-mediated host immunity in Mycobacterium tuberculosis-infected macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.962306
Abstract: MAFB, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B, has been identified as a candidate gene for early tuberculosis (TB) onset in Thai and Japanese populations. Here, we investigated the genome-wide transcriptional profiles of MAFB-knockdown (KD)… read more here.
Keywords: mycobacterium tuberculosis; mafb; infected macrophages; host immunity ... See more keywords