Evolution of Melanoma Antigen-A11 (MAGEA11) During Primate Phylogeny
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Evolution"
DOI: 10.1007/s00239-018-9838-8
Abstract: Melanoma antigen-A11 (MAGE-A11) is an X-linked and primate-specific steroid hormone receptor transcriptional coregulator and proto-oncogenic protein whose increased expression promotes the growth of prostate cancer. The MAGEA11 gene is expressed at low levels in normal… read more here.
Keywords: mage a11; evolution; a11; melanoma antigen ... See more keywords
Epigenetic modulation combined with PD-1/PD-L1 blockade enhances immunotherapy based on MAGE-A11 antigen-specific CD8+ T cells against esophageal carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Carcinogenesis"
DOI: 10.1093/carcin/bgaa057
Abstract: Cancer testis antigens (CTAs) are promising targets for T cell-based immunotherapy and studies have shown that certain CT genes are epigenetically depressed in cancer cells through DNA demethylation. Melanoma-associated antigen A11 (MAGE-A11) is a CTA… read more here.
Keywords: cancer; mage a11; esophageal cancer; cancer cells ... See more keywords