Harnessing the Magic Methyl Effect: Discovery of CLPP-2068 as a Novel HsClpP Activator for the Treatment of Diffuse Large B-Cell Lymphoma.
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DOI: 10.1021/acs.jmedchem.4c02016
Abstract: The "magic methyl effect" has facilitated the successful development of numerous pharmaceutical compounds. During the development of HsClpP activators, we found that incorporating methyl groups into the bicyclic imipridone scaffolds significantly enhanced the activator activity… read more here.
Keywords: hsclpp; clpp 2068; magic methyl; methyl effect ... See more keywords