eEF2 diphthamide modification restrains spurious frameshifting to maintain translational fidelity.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad461
Abstract: Diphthamide (DPH), a conserved amino acid modification on eukaryotic translation elongation factor eEF2, is synthesized via a complex, multi-enzyme pathway. While DPH is non-essential for cell viability and its function has not been resolved, diphtheria… read more here.
Keywords: modification; elongation; fidelity; maintain translational ... See more keywords