Recruitment and reinforcement: maintaining epigenetic silencing
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DOI: 10.1007/s11427-018-9276-7
Abstract: Cells need to appropriately balance transcriptional stability and adaptability in order to maintain their identities while responding robustly to various stimuli. Eukaryotic cells use an elegant “epigenetic” system to achieve this functionality. “Epigenetics” is referred… read more here.
Keywords: epigenetic silencing; information; maintaining epigenetic; recruitment reinforcement ... See more keywords
Zinc finger protein 280C contributes to colorectal tumorigenesis by maintaining epigenetic repression at H3K27me3-marked loci
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DOI: 10.1073/pnas.2120633119
Abstract: Significance This study uncovered the role of ZNF280C, a known DNA damage response protein, as a tumorigenic transcription regulator that contributes to colorectal tumorigenesis and metastasis through maintaining an epigenetic repression program at key cancer… read more here.
Keywords: maintaining epigenetic; colorectal tumorigenesis; epigenetic repression; contributes colorectal ... See more keywords