Maintenance mechanisms of circuit-integrated axons
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2018.08.007
Abstract: Adult, circuit-integrated neurons must be maintained and supported for the life span of their host. The attenuation of either maintenance or plasticity leads to impaired circuit function and ultimately to neurodegenerative disorders. Over the last… read more here.
Keywords: integrated axons; mechanisms circuit; maintenance; maintenance mechanisms ... See more keywords
A systematic look at a childhood tumor
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.362.6419.1124-a
Abstract: Cancer Neuroblastomas—the most common tumor type in infants—develop from fetal nerve cells, and their clinical course is highly variable. Some neuroblastomas are fatal despite treatment, whereas others respond well to treatment and some undergo spontaneous… read more here.
Keywords: look childhood; risk tumors; maintenance mechanisms; telomere maintenance ... See more keywords
A mechanistic classification of clinical phenotypes in neuroblastoma
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.aat6768
Abstract: A systematic look at a childhood tumor Neuroblastomas—the most common tumor type in infants—develop from fetal nerve cells, and their clinical course is highly variable. Some neuroblastomas are fatal despite treatment, whereas others respond well… read more here.
Keywords: mechanistic classification; telomere maintenance; maintenance mechanisms; tumor ... See more keywords
Abstract 4881: Dissecting telomere maintenance mechanisms in neuroblastoma
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-4881
Abstract: Background. Telomere maintenance is a major cancer hallmark and has recently attracted attention as an oncogenic mechanism in the pediatric malignancy, neuroblastoma (NBL), due to detection of frequent structural rearrangements near the telomerase (TERT) gene.… read more here.
Keywords: methylation; maintenance; high risk; maintenance mechanisms ... See more keywords
Genome maintenance in retinoblastoma: Implications for therapeutic vulnerabilities
Sign Up to like & getrecommendations! Published in 2022 at "Oncology Letters"
DOI: 10.3892/ol.2022.13312
Abstract: Retinoblastoma (RB) is a pediatric ocular malignancy that is initiated mostly by biallelic inactivation of the RB transcriptional corepressor 1 (RB1) tumor suppressor gene in the developing retina. Unlike the prevailing prediction based on multiple… read more here.
Keywords: maintenance; maintenance retinoblastoma; genome maintenance; maintenance mechanisms ... See more keywords