MAIT cells as attractive vaccine targets
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13488
Abstract: Mucosal‐associated invariant T (MAIT) cells are a subset of T cells that perform innate‐like immunity functions upon recognition of small molecule vitamin B metabolites presented by the MHC, class I‐related protein‐1 (MR1). MAIT cells are… read more here.
Keywords: vaccine targets; attractive vaccine; mait cells; mait ... See more keywords
Human MAIT cells are rapidly activated by Aspergillus spp. in an APC‐dependent manner
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201747312
Abstract: Mucosal associated invariant T cells (MAIT cells) are innate‐like T cells (TC) which are known to be activated by several bacteria and viruses. However, activation of MAIT cells by moulds, such as the opportunistic human… read more here.
Keywords: mait cells; dependent manner; mait; apc dependent ... See more keywords
4-1BB expression on MAIT cells is associated with enhanced IFN-γ production and depends on IL-2.
Sign Up to like & getrecommendations! Published in 2018 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2018.03.013
Abstract: The role of MAIT cells in immunity against Mycobacterium tuberculosis infection in humans is still largely unexplored. In this study, we investigated the functional role of 4-1BB on MAIT cells. We found that 4-1BB was… read more here.
Keywords: mait cells; expression mait; mait; ifn production ... See more keywords
TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions
Sign Up to like & getrecommendations! Published in 2019 at "Cell Reports"
DOI: 10.1016/j.celrep.2019.08.050
Abstract: Summary MAIT cells are an unconventional T cell population that can be activated through both TCR-dependent and TCR-independent mechanisms. Here, we examined the impact of combinations of TCR-dependent and TCR-independent signals in human CD8+ MAIT… read more here.
Keywords: mait cells; mait; tissue; tcr independent ... See more keywords
MAIT Cell Development and Functions: the Microbial Connection.
Sign Up to like & getrecommendations! Published in 2020 at "Immunity"
DOI: 10.1016/j.immuni.2020.09.009
Abstract: Mucosal-associated invariant T (MAIT) cells are an evolutionarily conserved T cell subset, which reacts to most bacteria through T cell receptor (TCR)-mediated recognition of metabolites derived from the vitamin B2 biosynthetic pathway. Microbiota-derived signals affect all stages… read more here.
Keywords: mait cell; mait cells; cell development; mait ... See more keywords
A TCR-Dependent Tissue Repair Potential of MAIT Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in immunology"
DOI: 10.1016/j.it.2019.09.001
Abstract: Three studies published in Cell Reports (Hinks et al., Lamichhane et al., and Leng et al.) describe the transcriptome of human and mouse mucosal-associated invariant T (MAIT) cells after cognate and noncognate stimulation. The results confirm the variability… read more here.
Keywords: mait cells; tcr dependent; tissue repair; mait ... See more keywords
Mucosal-Associated Invariant T Cells Redistribute to the Peritoneal Cavity During Spontaneous Bacterial Peritonitis and Contribute to Peritoneal Inflammation
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2020.01.003
Abstract: Background & Aims Mucosal-associated invariant T (MAIT) cells are depleted from blood in patients with advanced liver disease and show features of immune dysfunction. Because circulating MAIT cells differ from organ-resident MAIT cells, we aimed… read more here.
Keywords: associated invariant; mait cells; peritoneal mait; mait ... See more keywords
Mouse models illuminate MAIT cell biology.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular immunology"
DOI: 10.1016/j.molimm.2020.12.007
Abstract: The field of mucosal-associated invariant T cell (MAIT) biology has grown rapidly since the identification of the vitamin-B-based antigens recognised by these specialised T cells. Over the past few years, our understanding of the complexities… read more here.
Keywords: mait cell; mait cells; mait; biology ... See more keywords
MAIT cells reside in the female genital mucosa and are biased towards IL-17 and IL-22 production in response to bacterial stimulation
Sign Up to like & getrecommendations! Published in 2017 at "Mucosal immunology"
DOI: 10.1038/mi.2016.30
Abstract: The female genital tract (FGT) mucosa is a critically important site for immune defense against microbes. Mucosal-associated invariant T (MAIT) cells are an innate-like T-cell population that recognizes microbial riboflavin metabolite antigens in an MR1-dependent… read more here.
Keywords: mait cells; mait; blood; genital mucosa ... See more keywords
MR1 Restricted Mucosal-Associated Invariant T (MAIT) Cells Respond to Mycobacterial Vaccination and Infection in Nonhuman Primates
Sign Up to like & getrecommendations! Published in 2017 at "Mucosal immunology"
DOI: 10.1038/mi.2016.91
Abstract: Studies on mucosal-associated invariant T cells (MAITs) in nonhuman primates (NHP), a physiologically relevant model of human immunity, are handicapped due to a lack of macaque MAIT-specific reagents. Here we show that while MR1 ligand-contact… read more here.
Keywords: associated invariant; mr1; mait; mucosal associated ... See more keywords
MAIT cells regulate NK cell-mediated tumor immunity
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-25009-4
Abstract: The function of MR1-restricted mucosal-associated invariant T (MAIT) cells in tumor immunity is unclear. Here we show that MAIT cell-deficient mice have enhanced NK cell-dependent control of metastatic B16F10 tumor growth relative to control mice.… read more here.
Keywords: mait cells; cell; tumor immunity; mait ... See more keywords