MAIT Cell Development and Functions: the Microbial Connection.
Sign Up to like & getrecommendations! Published in 2020 at "Immunity"
DOI: 10.1016/j.immuni.2020.09.009
Abstract: Mucosal-associated invariant T (MAIT) cells are an evolutionarily conserved T cell subset, which reacts to most bacteria through T cell receptor (TCR)-mediated recognition of metabolites derived from the vitamin B2 biosynthetic pathway. Microbiota-derived signals affect all stages… read more here.
Keywords: mait cell; mait cells; cell development; mait ... See more keywords
Mouse models illuminate MAIT cell biology.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular immunology"
DOI: 10.1016/j.molimm.2020.12.007
Abstract: The field of mucosal-associated invariant T cell (MAIT) biology has grown rapidly since the identification of the vitamin-B-based antigens recognised by these specialised T cells. Over the past few years, our understanding of the complexities… read more here.
Keywords: mait cell; mait cells; mait; biology ... See more keywords
Agonistic or antagonistic mucosal-associated invariant T (MAIT) cell activity is determined by the 6-alkylamino substituent on uracil MR1 ligands.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc00247j
Abstract: Mucosal-associated invariant T (MAIT) are a subset of innate-like T cells that are activated by uracil ligands presented by MR1. For the first time, we demonstrate that changes to the 6-aminoalkyl chain on uracil agonist… read more here.
Keywords: mait cell; associated invariant; mait; mucosal associated ... See more keywords
The CD4−CD8− MAIT cell subpopulation is a functionally distinct subset developmentally related to the main CD8+ MAIT cell pool
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1812273115
Abstract: Significance Mucosa-associated invariant T (MAIT) cells are unconventional innate-like T cells recognizing microbial riboflavin metabolites presented by the monomorphic MR1 molecule. Here, we show that the CD8+CD4− and CD8−CD4− subpopulations of human MAIT cells represent… read more here.
Keywords: mait cell; mait cells; cd8 mait; mait ... See more keywords
Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2007472117
Abstract: Significance Nontyphoidal Salmonella serotypes are a common cause of self-limiting diarrhoeal illnesses in healthy adults. However, recently, a highly invasive multidrug resistant Salmonella Typhimurium sequence type 313 has emerged as a major cause of morbidity… read more here.
Keywords: mait cell; salmonella; mait cells; mait ... See more keywords
Prostaglandins differentially modulate mucosal‐associated invariant T‐cell activation and function according to stimulus
Sign Up to like & getrecommendations! Published in 2022 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12617
Abstract: Mucosal‐associated invariant T (MAIT) cells are an innate‐like T‐cell type conserved in many mammals and especially abundant in humans. Their semi‐invariant T‐cell receptor (TCR) recognizes the major histocompatibility complex–like molecule MR1 presenting riboflavin intermediates associated… read more here.
Keywords: cell; tcr; mait; cell activation ... See more keywords
Augmentation of the Riboflavin-Biosynthetic Pathway Enhances Mucosa-Associated Invariant T (MAIT) Cell Activation and Diminishes Mycobacterium tuberculosis Virulence
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.03865-21
Abstract: Mucosa-associated invariant T (MAIT) cells are an important subset of innate lymphocytes that recognize microbial ligands derived from the riboflavin biosynthesis pathway and mediate antimicrobial immune responses. Modulated MAIT cell responses have been noted in… read more here.
Keywords: mait; tuberculosis; cell activation; mait cell ... See more keywords
Stimulatory MAIT cell antigens reach the circulation and are efficiently metabolised and presented by human liver cells
Sign Up to like & getrecommendations! Published in 2022 at "Gut"
DOI: 10.1136/gutjnl-2021-324478
Abstract: Objective Mucosal-associated invariant T (MAIT) cells are the most abundant T cells in human liver. They respond to bacterial metabolites presented by major histocompatibility complex-like molecule MR1. MAIT cells exert regulatory and antimicrobial functions and… read more here.
Keywords: liver; mait cells; mait; liver cells ... See more keywords
Chronic Obstructive Pulmonary Disease and Cigarette Smoke Lead to Dysregulated MAIT Cell Activation.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2022-0131oc
Abstract: Chronic obstructive pulmonary disease (COPD) is associated with airway inflammation, increased infiltration by CD8+ T lymphocytes, and infection-driven exacerbations. Although cigarette smoke (CS) is the leading risk factor for COPD, the mechanisms driving development of… read more here.
Keywords: cell; copd; mait; cell activation ... See more keywords
Alcohol Abstinence Does Not Fully Reverse Abnormalities of Mucosal-Associated Invariant T Cells in the Blood of Patients With Alcoholic Hepatitis
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Translational Gastroenterology"
DOI: 10.14309/ctg.0000000000000052
Abstract: OBJECTIVES: Alcoholic hepatitis (AH) develops in approximately 30% of chronic heavy drinkers. The immune system of patients with AH is hyperactivated, yet ineffective against infectious diseases. Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that… read more here.
Keywords: mait cell; mait cells; alcohol abstinence; mait ... See more keywords
Factors Influencing Functional Heterogeneity in Human Mucosa-Associated Invariant T Cells
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01602
Abstract: Mucosa-associated invariant T (MAIT) cells are unconventional innate-like T cells that recognize microbial riboflavin metabolites presented by the monomorphic MHC class I-related (MR1) molecule. Despite the high level of evolutionary conservation of MR1 and the… read more here.
Keywords: mait cell; associated invariant; mait cells; mucosa associated ... See more keywords