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   Articles with "mait cell" as a keyword



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MAIT Cell Development and Functions: the Microbial Connection.

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recommendations! Published in 2020 at "Immunity"

DOI: 10.1016/j.immuni.2020.09.009

Abstract: Mucosal-associated invariant T (MAIT) cells are an evolutionarily conserved T cell subset, which reacts to most bacteria through T cell receptor (TCR)-mediated recognition of metabolites derived from the vitamin B2 biosynthetic pathway. Microbiota-derived signals affect all stages… read more here.

Keywords: mait cell; mait cells; cell development; mait ... See more keywords
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Mouse models illuminate MAIT cell biology.

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recommendations! Published in 2020 at "Molecular immunology"

DOI: 10.1016/j.molimm.2020.12.007

Abstract: The field of mucosal-associated invariant T cell (MAIT) biology has grown rapidly since the identification of the vitamin-B-based antigens recognised by these specialised T cells. Over the past few years, our understanding of the complexities… read more here.

Keywords: mait cell; mait cells; mait; biology ... See more keywords
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Agonistic or antagonistic mucosal-associated invariant T (MAIT) cell activity is determined by the 6-alkylamino substituent on uracil MR1 ligands.

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recommendations! Published in 2020 at "Chemical communications"

DOI: 10.1039/d0cc00247j

Abstract: Mucosal-associated invariant T (MAIT) are a subset of innate-like T cells that are activated by uracil ligands presented by MR1. For the first time, we demonstrate that changes to the 6-aminoalkyl chain on uracil agonist… read more here.

Keywords: mait cell; associated invariant; mait; mucosal associated ... See more keywords

The CD4−CD8− MAIT cell subpopulation is a functionally distinct subset developmentally related to the main CD8+ MAIT cell pool

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recommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.1812273115

Abstract: Significance Mucosa-associated invariant T (MAIT) cells are unconventional innate-like T cells recognizing microbial riboflavin metabolites presented by the monomorphic MR1 molecule. Here, we show that the CD8+CD4− and CD8−CD4− subpopulations of human MAIT cells represent… read more here.

Keywords: mait cell; mait cells; cd8 mait; mait ... See more keywords

Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease

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recommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2007472117

Abstract: Significance Nontyphoidal Salmonella serotypes are a common cause of self-limiting diarrhoeal illnesses in healthy adults. However, recently, a highly invasive multidrug resistant Salmonella Typhimurium sequence type 313 has emerged as a major cause of morbidity… read more here.

Keywords: mait cell; salmonella; mait cells; mait ... See more keywords

Human MAIT cell response profiles biased toward IL-17 or IL-10 are distinct effector states directed by the cytokine milieu

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recommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2414230122

Abstract: Significance Mucosal-associated invariant T (MAIT) cells are unconventional T lymphocytes present in all healthy humans and play an important role in immunity via recognition of antigens that are shared between many microbes. In this study,… read more here.

Keywords: human mait; mait cells; cell response; mait ... See more keywords

Prostaglandins differentially modulate mucosal‐associated invariant T‐cell activation and function according to stimulus

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recommendations! Published in 2022 at "Immunology and Cell Biology"

DOI: 10.1111/imcb.12617

Abstract: Mucosal‐associated invariant T (MAIT) cells are an innate‐like T‐cell type conserved in many mammals and especially abundant in humans. Their semi‐invariant T‐cell receptor (TCR) recognizes the major histocompatibility complex–like molecule MR1 presenting riboflavin intermediates associated… read more here.

Keywords: cell; tcr; mait; cell activation ... See more keywords

MAIT cell homing in intestinal homeostasis and inflammation

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recommendations! Published in 2025 at "Science Advances"

DOI: 10.1126/sciadv.adu4172

Abstract: Mucosa-associated invariant T (MAIT) cells are a large population of unconventional T cells widely distributed in the human gastrointestinal tract. Their homing to the gut is central to maintaining mucosal homeostasis and immunity. This review… read more here.

Keywords: cell homing; homeostasis inflammation; mait cell; mait ... See more keywords

Augmentation of the Riboflavin-Biosynthetic Pathway Enhances Mucosa-Associated Invariant T (MAIT) Cell Activation and Diminishes Mycobacterium tuberculosis Virulence

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recommendations! Published in 2022 at "mBio"

DOI: 10.1128/mbio.03865-21

Abstract: Mucosa-associated invariant T (MAIT) cells are an important subset of innate lymphocytes that recognize microbial ligands derived from the riboflavin biosynthesis pathway and mediate antimicrobial immune responses. Modulated MAIT cell responses have been noted in… read more here.

Keywords: mait; tuberculosis; cell activation; mait cell ... See more keywords

Stimulatory MAIT cell antigens reach the circulation and are efficiently metabolised and presented by human liver cells

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recommendations! Published in 2022 at "Gut"

DOI: 10.1136/gutjnl-2021-324478

Abstract: Objective Mucosal-associated invariant T (MAIT) cells are the most abundant T cells in human liver. They respond to bacterial metabolites presented by major histocompatibility complex-like molecule MR1. MAIT cells exert regulatory and antimicrobial functions and… read more here.

Keywords: liver; mait cells; mait; liver cells ... See more keywords

Chronic Obstructive Pulmonary Disease and Cigarette Smoke Lead to Dysregulated MAIT Cell Activation.

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recommendations! Published in 2022 at "American journal of respiratory cell and molecular biology"

DOI: 10.1165/rcmb.2022-0131oc

Abstract: Chronic obstructive pulmonary disease (COPD) is associated with airway inflammation, increased infiltration by CD8+ T lymphocytes, and infection-driven exacerbations. Although cigarette smoke (CS) is the leading risk factor for COPD, the mechanisms driving development of… read more here.

Keywords: cell; copd; mait; cell activation ... See more keywords