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Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13488
Abstract: Mucosal‐associated invariant T (MAIT) cells are a subset of T cells that perform innate‐like immunity functions upon recognition of small molecule vitamin B metabolites presented by the MHC, class I‐related protein‐1 (MR1). MAIT cells are…
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Keywords:
vaccine targets;
attractive vaccine;
mait cells;
mait ... See more keywords
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Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201747312
Abstract: Mucosal associated invariant T cells (MAIT cells) are innate‐like T cells (TC) which are known to be activated by several bacteria and viruses. However, activation of MAIT cells by moulds, such as the opportunistic human…
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Keywords:
mait cells;
dependent manner;
mait;
apc dependent ... See more keywords
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Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6548-9_17
Abstract: The mucosa-associated invariant T (MAIT) cells are a large and relatively recently described innate-like antimicrobial T cell subset in humans. The study of human MAIT cells is still in its infancy, and many aspects of…
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Keywords:
mait cells;
transcription factor;
human mait;
flow cytometry ... See more keywords
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Published in 2019 at "Seminars in Immunopathology"
DOI: 10.1007/s00281-019-00740-9
Abstract: Invariant and semi-invariant T cells are emerging as important regulators of host environment interactions at barrier tissues such as the airway and skin. In contrast to conventional T cells, invariant natural killer T (iNKT) cells…
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Keywords:
skin airways;
mait cells;
inkt cells;
inflammation ... See more keywords
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Published in 2018 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2018.03.013
Abstract: The role of MAIT cells in immunity against Mycobacterium tuberculosis infection in humans is still largely unexplored. In this study, we investigated the functional role of 4-1BB on MAIT cells. We found that 4-1BB was…
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Keywords:
mait cells;
expression mait;
mait;
ifn production ... See more keywords
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Published in 2019 at "Cell Reports"
DOI: 10.1016/j.celrep.2019.08.050
Abstract: Summary MAIT cells are an unconventional T cell population that can be activated through both TCR-dependent and TCR-independent mechanisms. Here, we examined the impact of combinations of TCR-dependent and TCR-independent signals in human CD8+ MAIT…
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Keywords:
mait cells;
mait;
tissue;
tcr independent ... See more keywords
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Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.08.054
Abstract: Mucosal-associated invariant T (MAIT) cells can be activated via either their T cell receptor (TCR), which recognizes MR1-bound pyrimidines derived from microbial riboflavin biosynthesis, or via cytokines. These two modes of activation may act in concert…
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Keywords:
tcr cytokine;
mait cells;
associated invariant;
immune responses ... See more keywords
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Published in 2020 at "Immunity"
DOI: 10.1016/j.immuni.2020.09.009
Abstract: Mucosal-associated invariant T (MAIT) cells are an evolutionarily conserved T cell subset, which reacts to most bacteria through T cell receptor (TCR)-mediated recognition of metabolites derived from the vitamin B2 biosynthetic pathway. Microbiota-derived signals affect all stages…
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Keywords:
mait cell;
mait cells;
cell development;
mait ... See more keywords
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Published in 2019 at "Trends in immunology"
DOI: 10.1016/j.it.2019.09.001
Abstract: Three studies published in Cell Reports (Hinks et al., Lamichhane et al., and Leng et al.) describe the transcriptome of human and mouse mucosal-associated invariant T (MAIT) cells after cognate and noncognate stimulation. The results confirm the variability…
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Keywords:
mait cells;
tcr dependent;
tissue repair;
mait ... See more keywords
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Published in 2020 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2020.01.003
Abstract: Background & Aims Mucosal-associated invariant T (MAIT) cells are depleted from blood in patients with advanced liver disease and show features of immune dysfunction. Because circulating MAIT cells differ from organ-resident MAIT cells, we aimed…
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Keywords:
associated invariant;
mait cells;
peritoneal mait;
mait ... See more keywords
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Published in 2020 at "Molecular immunology"
DOI: 10.1016/j.molimm.2020.12.007
Abstract: The field of mucosal-associated invariant T cell (MAIT) biology has grown rapidly since the identification of the vitamin-B-based antigens recognised by these specialised T cells. Over the past few years, our understanding of the complexities…
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Keywords:
mait cell;
mait cells;
mait;
biology ... See more keywords