Major Bleeding With Apixaban vs Aspirin: A Subanalysis of the ARTESiA Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2025 at "JAMA cardiology"
DOI: 10.1001/jamacardio.2025.4151
Abstract: Importance The Apixaban for the Reduction of Thromboembolism in Patients With Device-Detected Subclinical Atrial Fibrillation (ARTESiA) randomized clinical trial showed that in patients with subclinical atrial fibrillation (SCAF) apixaban, compared with aspirin, reduced stroke/systemic embolism… read more here.
Keywords: subanalysis artesia; major bleeding; clinical trial; artesia randomized ... See more keywords
Comparative Risk of Hospitalized Bleeding of P2Y12 Inhibitors for Secondary Prophylaxis in Acute Coronary Syndrome After Percutaneous Coronary Intervention
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2806
Abstract: In closely monitored randomized controlled trials (RCTs), newer P2Y12 agents (ticagrelor and prasugrel) reduced cardiovascular outcomes compared with clopidogrel following percutaneous coronary intervention (PCI) in acute coronary syndrome. However, these RCTs indicated a higher bleeding… read more here.
Keywords: p2y12; major bleeding; prasugrel; clopidogrel ... See more keywords
Impact of Age and Factor Xa Inhibitor Concentrations on Bleeding Risk in Patients with Atrial Fibrillation
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.3654
Abstract: This study aimed to analyze differences in the exposure‐response relationship for factor Xa inhibitors (FXaI) between patients aged ≥ 80 and read more here.
Keywords: age; major bleeding; bleeding risk; risk ... See more keywords
Bleeding risk in patients with venous thromboembolic events treated with new oral anticoagulants
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-020-02319-w
Abstract: New oral anticoagulants (NOACs) is the preferred treatment in secondary prophylaxis of venous thromboembolic events (VTE). The aim of this study was to investigate possible risk factors associated with major bleeding in VTE-patients treated with… read more here.
Keywords: thromboembolic events; risk; oral anticoagulants; major bleeding ... See more keywords
Presence of Geriatric Conditions Is Prognostic of Major Bleeding in Older Patients with Atrial Fibrillation: a Cohort Study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of General Internal Medicine"
DOI: 10.1007/s11606-022-07410-x
Abstract: In older patients with atrial fibrillation (AF), physical, cognitive, and psychosocial limitations are prevalent. The prognostic value of these conditions for major bleeding is unclear. To determine whether geriatric conditions are prospectively associated with major… read more here.
Keywords: geriatric conditions; bleeding older; atrial fibrillation; older patients ... See more keywords
Inferior vena cava filter in patients with venous thromboembolism and major bleeding events: building the evidence
Sign Up to like & getrecommendations! Published in 2019 at "Internal and Emergency Medicine"
DOI: 10.1007/s11739-019-02107-2
Abstract: Anticoagulation is the first−line treatment in almost all patients with an acute episode of venous thromboembolism (VTE) [1]. Vena cava interruption by percutaneous inser‐ tion of an inferior vena cava filter (IVCF) is not infrequently… read more here.
Keywords: anticoagulation; risk; ivcf; vena cava ... See more keywords
Left atrial appendage closure in atrial fibrillation patients with prior major bleeding or ineligible for oral anticoagulation
Sign Up to like & getrecommendations! Published in 2019 at "Netherlands Heart Journal"
DOI: 10.1007/s12471-019-1295-5
Abstract: AimsOral anticoagulation (OAC) reduces the ischaemic stroke risk in patients with atrial fibrillation (AF), but in turn leads to an increased risk of adverse bleeding events. Alternatively, left atrial appendage closure (LAAC) using a mechanical device… read more here.
Keywords: atrial fibrillation; appendage closure; major bleeding; atrial appendage ... See more keywords
Reversal of Apixaban and Rivaroxaban Using Activated Prothrombin Complex Concentrates in Patients with Major Bleeding
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Cardiovascular Drugs"
DOI: 10.1007/s40256-019-00383-z
Abstract: Background Clinical experience with using activated prothrombin complex concentrates (aPCCs) to reverse the effects of factor Xa inhibitors is limited. Objectives Our objective was to assess the achievement of effective clinical hemostasis using aPCC in… read more here.
Keywords: apixaban rivaroxaban; major bleeding; activated prothrombin; hemostasis ... See more keywords
Balancing the risk of spontaneous ischemic and major bleeding events in acute coronary syndromes
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DOI: 10.1016/j.ahj.2017.01.010
Abstract: Background Evaluation of antithrombotic treatments for acute coronary syndromes (ACS) requires balancing ischemic and bleeding risks to assess net benefit. We sought to compare the relative effects of ischemic and bleeding events on mortality. Methods… read more here.
Keywords: ischemic bleeding; bleeding events; spontaneous ischemic; major bleeding ... See more keywords
Radial versus femoral vascular access in ST‐elevation myocardial infarction: Are the results of femoral operators unfairly represented in observational research?
Sign Up to like & getrecommendations! Published in 2019 at "American Heart Journal"
DOI: 10.1016/j.ahj.2018.12.009
Abstract: Background: Recent randomized controlled trials comparing femoral and radial access in primary percutaneous coronary intervention (PPCI) have shown conflicting results regarding the incidence of major adverse cardiovascular events (MACE) and major bleeding. Methods: Using data… read more here.
Keywords: bleeding events; myocardial infarction; major bleeding; femoral operators ... See more keywords
Effectiveness and Safety of Rivaroxaban Compared to Acenocumarol after Infrainguinal Surgical Revascularization.
Sign Up to like & getrecommendations! Published in 2019 at "Annals of vascular surgery"
DOI: 10.1016/j.avsg.2018.06.008
Abstract: BACKGROUND Optimal antithrombotic therapy after lower limb infrainguinal revascularization remains a controversial topic. The use of anticoagulants, alone or in combination with antiplatelet drugs, can potentially improve patency rate and limb salvage, particularly in patients… read more here.
Keywords: rivaroxaban; safety; acenocumarol infrainguinal; major bleeding ... See more keywords