Effectiveness of Universal School-Based Screening vs Targeted Screening for Major Depressive Disorder Among Adolescents
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DOI: 10.1001/jamanetworkopen.2019.14427
Abstract: Key Points Question Is universal school-based screening for adolescent major depressive disorder (MDD) more effective than the existing process of targeted screening based on observable behaviors of concern? Findings Screening in High Schools to Identify,… read more here.
Keywords: school based; depressive disorder; universal school; major depressive ... See more keywords
Effectiveness of Genotype-Specific Tricyclic Antidepressant Dosing in Patients With Major Depressive Disorder
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DOI: 10.1001/jamanetworkopen.2023.12443
Abstract: Key Points Question Does pharmacogenetics-informed (CYP2D6 and CYP2C19 genotypes) dosing of tricyclic antidepressants result in faster attainment of therapeutic plasma concentrations, higher effectiveness, and fewer and less severe adverse effects compared with usual treatment? Findings… read more here.
Keywords: effectiveness genotype; depressive disorder; patients major; major depressive ... See more keywords
Genetic Liabilities Differentiating Bipolar Disorder, Schizophrenia, and Major Depressive Disorder, and Phenotypic Heterogeneity in Bipolar Disorder
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DOI: 10.1001/jamapsychiatry.2022.2594
Abstract: Key Points Question Are there etiological associations between clinical heterogeneity in participants with bipolar disorder and components of genetic liability that are shared between schizophrenia, bipolar disorder, and major depressive disorder and components that differentiate… read more here.
Keywords: heterogeneity; differentiating bipolar; bipolar disorder; depressive disorder ... See more keywords
Efficacy of Adjunctive D-Cycloserine to Intermittent Theta-Burst Stimulation for Major Depressive Disorder: A Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2022.3255
Abstract: Importance The antidepressant effects of transcranial magnetic stimulation protocols for major depressive disorder (MDD) are thought to depend on synaptic plasticity. The theta-burst stimulation (TBS) protocol synaptic plasticity is known to be N-methyl-D-aspartate (NMDA)-receptor dependent,… read more here.
Keywords: itbs plus; stimulation; cycloserine; clinical trial ... See more keywords
Efficacy and Safety of Ketamine vs Electroconvulsive Therapy Among Patients With Major Depressive Episode: A Systematic Review and Meta-analysis.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2022.3352
Abstract: Importance Whether ketamine is as effective as electroconvulsive therapy (ECT) among patients with major depressive episode remains unknown. Objective To systematically review and meta-analyze data about clinical efficacy and safety for ketamine and ECT in… read more here.
Keywords: review meta; ketamine; depressive episode; patients major ... See more keywords
Gene Expression has Distinct Associations with Brain Structure and Function in Major Depressive Disorder
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DOI: 10.1002/advs.202205486
Abstract: Major depressive disorder (MDD) is associated with structural and functional brain abnormalities. MDD as well as brain anatomy and function are influenced by genetic factors, but the role of gene expression remains unclear. Here, this… read more here.
Keywords: function; brain; gene expression; gene ... See more keywords
Vortioxetine versus placebo in major depressive disorder comorbid with social anxiety disorder
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DOI: 10.1002/da.22702
Abstract: Major Depressive Disorder (MDD) and Social Anxiety Disorder (SAD) are highly comorbid, yet the combined condition has not been subject to any placebo‐controlled treatment trials. This study reports a trial of vortioxetine, an antidepressant that… read more here.
Keywords: depressive disorder; anxiety; disorder; major depressive ... See more keywords
Error‐related brain activity in adolescents with obsessive‐compulsive disorder and major depressive disorder
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DOI: 10.1002/da.22767
Abstract: The error‐related negativity (ERN) is a negative deflection in the event‐related potential following a mistake that is often increased in patients with obsessive‐compulsive disorder (OCD). The relationship of the ERN to comorbid major depressive disorder… read more here.
Keywords: depressive disorder; compulsive disorder; obsessive compulsive; disorder ... See more keywords
Familial aggregation of major depressive disorder in an African‐American community
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DOI: 10.1002/da.22775
Abstract: African Americans (AAs) with major depressive disorder (MDD) experience more impairment and poorer treatment outcomes relative to Whites, yet are underrepresented in family studies of MDD. This is the first study to investigate the familial… read more here.
Keywords: depressive disorder; familial aggregation; major depressive; aggregation major ... See more keywords
Course of major depressive disorder after pregnancy and the postpartum period
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DOI: 10.1002/da.22836
Abstract: Maternal major depressive disorder (MDD) has an adverse effect on child development and increases risk for child psychopathology. It is paramount to understand the course of maternal depression during the childhood years particularly before, during,… read more here.
Keywords: pregnancy; depressive disorder; course major; major depressive ... See more keywords
Social cognitive abilities predict psychosocial dysfunction in major depressive disorder
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DOI: 10.1002/da.22844
Abstract: Major depressive disorder (MDD) is associated with social cognitive deficits (e.g., poor affect recognition and impaired theory of mind). However, the contribution of social cognitive issues to psychosocial dysfunction in MDD (e.g., occupational functioning and… read more here.
Keywords: depressive disorder; psychosocial dysfunction; major depressive; social cognitive ... See more keywords