A Major Disease-Related Point Mutation in Spastin Dramatically Alters the Dynamics and Allostery of the Motor.
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DOI: 10.1021/acs.biochem.4c00693
Abstract: Spastin is a microtubule-severing AAA+ ATPase that is highly expressed in neuronal cells and plays a crucial role in axonal growth, branching, and regeneration. This machine oligomerizes into hexamers in the presence of ATP and… read more here.
Keywords: dynamics allostery; major disease; mutation; spastin ... See more keywords