Mycobacterium tuberculosis Rv0191 is an efflux pump of major facilitator superfamily transporter regulated by Rv1353c.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2019.04.010
Abstract: Development of extensively drug resistant (XDR) strains and multidrug resistant (MDR) in Mycobacterium tuberculosis is caused by an efflux mechanism of antibiotics in the bacteria. Rv0191, predicted to a major facilitator superfamily transporter of efflux… read more here.
Keywords: facilitator superfamily; superfamily transporter; rv0191; major facilitator ... See more keywords
Outward open conformation of a Major Facilitator Superfamily multidrug/H+ antiporter provides insights into switching mechanism
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06306-x
Abstract: Multidrug resistance (MDR) poses a major challenge to medicine. A principle cause of MDR is through active efflux by MDR transporters situated in the bacterial membrane. Here we present the crystal structure of the major… read more here.
Keywords: medicine; facilitator superfamily; antiporter; conformation ... See more keywords
Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression
Sign Up to like & getrecommendations! Published in 2017 at "Open Biology"
DOI: 10.1098/rsob.170142
Abstract: Solute carriers (SLCs) are vital as they are responsible for a major part of the molecular transport over lipid bilayers. At present, there are 430 identified SLCs, of which 28 are called atypical SLCs of… read more here.
Keywords: slcs; solute carriers; facilitator superfamily; major facilitator ... See more keywords
Quorum Sensing Regulation of a Major Facilitator Superfamily Transporter Affects Multiple Streptococcal Virulence Factors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bacteriology"
DOI: 10.1128/jb.00176-22
Abstract: The production of virulence factors is a tightly regulated process in bacterial pathogens. Efforts to elucidate the mechanisms by which genes are regulated may advance the understanding of factors influencing pathogen behavior or cellular physiology.… read more here.
Keywords: facilitator superfamily; physiology; virulence; virulence factors ... See more keywords
Using cellular fitness to map the structure and function of a major facilitator superfamily effluxer
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Systems Biology"
DOI: 10.15252/msb.20177635
Abstract: The major facilitator superfamily (MFS) effluxers are prominent mediators of antimicrobial resistance. The biochemical characterization of MFS proteins is hindered by their complex membrane environment that makes in vitro biochemical analysis challenging. Since the physicochemical… read more here.
Keywords: facilitator superfamily; cellular fitness; major facilitator; using cellular ... See more keywords
Genome-Wide Analysis of Major Facilitator Superfamily and Its Expression in Response of Poplar to Fusarium oxysporum
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.769888
Abstract: The major facilitator superfamily (MFS) is one of the largest known membrane transporter families. MFSs are involved in many essential functions, but studies on the MFS family in poplar have not yet been reported. Here,… read more here.
Keywords: fusarium oxysporum; facilitator superfamily; analysis; major facilitator ... See more keywords
Identification of potential candidate vaccines against Mycobacterium ulcerans based on the major facilitator superfamily transporter protein
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1023558
Abstract: Buruli ulcer is a neglected tropical disease that is characterized by non-fatal lesion development. The causative agent is Mycobacterium ulcerans (M. ulcerans). There are no known vectors or transmission methods, preventing the development of control… read more here.
Keywords: superfamily transporter; transporter protein; facilitator superfamily; mycobacterium ulcerans ... See more keywords
The Major Facilitator Superfamily and Antimicrobial Resistance Efflux Pumps of the ESKAPEE Pathogen Staphylococcus aureus
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DOI: 10.3390/antibiotics12020343
Abstract: The ESKAPEE bacterial pathogen Staphylococcus aureus has posed a serious public health concern for centuries. Throughout its evolutionary course, S. aureus has developed strains with resistance to antimicrobial agents. The bacterial pathogen has acquired multidrug… read more here.
Keywords: staphylococcus aureus; resistance; pathogen staphylococcus; antimicrobial resistance ... See more keywords
Spontaneous Suppressors against Debilitating Transmembrane Mutants of CaMdr1 Disclose Novel Interdomain Communication via Signature Motifs of the Major Facilitator Superfamily
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Fungi"
DOI: 10.3390/jof8050538
Abstract: The Major Facilitator Superfamily (MFS) includes multiple families of proteins operating as uniporters, symporters and antiporters for a wide spectrum of substrates. Among them, the multidrug resistance-1 drug:H+ antiporter CaMdr1 from Candida albicans is responsible… read more here.
Keywords: signature motifs; major facilitator; drug; facilitator superfamily ... See more keywords
Ins and Outs of Rocker Switch Mechanism in Major Facilitator Superfamily of Transporters
Sign Up to like & getrecommendations! Published in 2023 at "Membranes"
DOI: 10.3390/membranes13050462
Abstract: The major facilitator superfamily (MFS) of transporters consists of three classes of membrane transporters: symporters, uniporters, and antiporters. Despite such diverse functions, MFS transporters are believed to undergo similar conformational changes within their distinct transport… read more here.
Keywords: switch mechanism; major facilitator; rocker switch; facilitator superfamily ... See more keywords