A novel β-hairpin peptide derived from the ARC repressor selectively interacts with the major groove of B-DNA.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.104836
Abstract: Transcription factors (TFs) have a remarkable role in the homeostasis of the organisms and there is a growing interest in how they recognize and interact with specific DNA sequences. TFs recognize DNA using a variety… read more here.
Keywords: peptide; dna; hairpin; major groove ... See more keywords
Targeting the Major Groove of the Palindromic d(GGCGCC)2 Sequence by Oligopeptide Derivatives of Anthraquinone Intercalators
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c00337
Abstract: GC-rich sequences are recurring motifs in oncogenes and retroviruses and could be targeted by noncovalent major-groove therapeutic ligands. We considered the palindromic sequence d(G1G2C3G4C5C6)2, and designed several oligopeptide derivatives of the anticancer intercalator mitoxantrone. The… read more here.
Keywords: targeting major; sequence; major groove; oligopeptide derivatives ... See more keywords
Denaturation of dsDNA Induced by Specific Major Groove Binding of Cadmium Ion to Thymine
Sign Up to like & getrecommendations! Published in 2017 at "ACS Omega"
DOI: 10.1021/acsomega.7b01377
Abstract: The toxicity of cadmium causes varying degrees of risk to organisms. The underlying mechanism has been conventionally attributed to Cd2+-ion-induced oxidative stress. Here, we propose that the Cd2+ ion directly and stably binds with the… read more here.
Keywords: major groove; ion; cadmium; thymine ... See more keywords
Arginine Forks Are a Widespread Motif to Recognize Phosphate Backbones and Guanine Nucleobases in the RNA Major Groove.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c09689
Abstract: RNA recognition by proteins is central to biology. Here we demonstrate the existence of a recurrent structural motif, the "arginine fork", that codifies arginine readout of cognate backbone and guanine nucleobase interactions in a variety… read more here.
Keywords: arginine fork; rna; arginine; major groove ... See more keywords
Gold nanoparticle design for RNA compaction.
Sign Up to like & getrecommendations! Published in 2022 at "Biointerphases"
DOI: 10.1116/6.0002043
Abstract: RNA-based therapeutics hold a great promise in treating a variety of diseases. However, double-stranded RNAs (dsRNAs) are inherently unstable, highly charged, and stiff macromolecules that require a delivery vehicle. Cationic ligand functionalized gold nanoparticles (AuNPs)… read more here.
Keywords: nanoparticle design; rna; design rna; major groove ... See more keywords