Profiles and Gender-Specifics of UDP-Glucuronosyltransferases and Sulfotransferases Expressions in the Major Metabolic Organs of Wild-Type and Efflux Transporter Knockout FVB Mice.
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DOI: 10.1021/acs.molpharmaceut.7b00435
Abstract: Hepatic and extrahepatic tissues participate in xenobiotic detoxication, carcinogen activation, prodrug processing, and estrogen regulation through UDP-glucuronosyltransferases (UGTs/Ugts) and sulfotransferases (SULTs/Sults). Wild-type (WT) and efflux transporter knockout (KO) FVB mice have been commonly used to… read more here.
Keywords: ugts sults; efflux transporter; mice; major metabolic ... See more keywords
From in vivo to in vitro: Major metabolic alterations take place in hepatocytes during and following isolation
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0190366
Abstract: The liver plays a key role in maintaining physiological homeostasis and hepatocytes are largely responsible for this. The use of isolated primary hepatocytes has become an essential tool for the study of nutrient physiology, xenobiotic… read more here.
Keywords: primary hepatocytes; major metabolic; liver; culture ... See more keywords