Vibrio cholerae cytotoxin MakA induces noncanonical autophagy resulting in the spatial inhibition of canonical autophagy.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cell science"
DOI: 10.1242/jcs.252015
Abstract: Autophagy plays an essential role in the defence against many microbial pathogens as a regulator of both innate and adaptive immunity. Among some pathogens, sophisticated mechanisms have evolved that promote their ability to evade or… read more here.
Keywords: vibrio cholerae; maka; cytotoxin maka; autophagy ... See more keywords
Protein-lipid interaction at low pH induces oligomerization of the MakA cytotoxin from Vibrio cholerae
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DOI: 10.7554/elife.73439
Abstract: The α-pore-forming toxins (α-PFTs) from pathogenic bacteria damage host cell membranes by pore formation. We demonstrate a remarkable, hitherto unknown mechanism by an α-PFT protein from Vibrio cholerae. As part of the MakA/B/E tripartite toxin,… read more here.
Keywords: protein lipid; vibrio cholerae; lipid interaction; maka ... See more keywords