Leveraging the wheat germ cell-free protein synthesis system to accelerate malaria vaccine development.
Sign Up to like & getrecommendations! Published in 2020 at "Parasitology international"
DOI: 10.1016/j.parint.2020.102224
Abstract: Vaccines against infectious diseases have had great successes in the history of public health. Major breakthroughs have occurred in the development of vaccine-based interventions against viral and bacterial pathogens through the application of classical vaccine… read more here.
Keywords: vaccine; protein synthesis; development; malaria vaccine ... See more keywords
First proven malaria vaccine rolled out in Africa — but doubts linger
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.1038/d41586-019-01342-z
Abstract: The RTS,S vaccine is up to 40% effective at preventing malaria in young children.The RTS,S vaccine is up to 40% effective at preventing malaria in young children. read more here.
Keywords: vaccine; vaccine rolled; rolled africa; first proven ... See more keywords
Heterotypic interactions drive antibody synergy against a malaria vaccine candidate
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28601-4
Abstract: Understanding mechanisms of antibody synergy is important for vaccine design and antibody cocktail development. Examples of synergy between antibodies are well-documented, but the mechanisms underlying these relationships often remain poorly understood. The leading blood-stage malaria… read more here.
Keywords: heterotypic interactions; antibody; malaria vaccine; antibody synergy ... See more keywords
RTS,S/AS01 malaria vaccine mismatch observed among Plasmodium falciparum isolates from southern and central Africa and globally
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-24585-8
Abstract: The RTS,S/AS01 malaria vaccine encompasses the central repeats and C-terminal of Plasmodium falciparum circumsporozoite protein (PfCSP). Although no Phase II clinical trial studies observed evidence of strain-specific immunity, recent studies show a decrease in vaccine… read more here.
Keywords: diversity; rts as01; plasmodium falciparum; malaria vaccine ... See more keywords
Barriers and facilitators to nationwide implementation of the malaria vaccine in Ghana
Sign Up to like & getrecommendations! Published in 2022 at "Health Policy and Planning"
DOI: 10.1093/heapol/czac077
Abstract: Abstract Interventions such as antimalarial drugs, bed nets and insecticides have helped curb the burden of malaria in the past decade, yet malaria remains a leading cause of morbidity and mortality in children below the… read more here.
Keywords: implementation malaria; barriers facilitators; malaria vaccine; nationwide implementation ... See more keywords
Safety, infectivity and immunogenicity of a genetically attenuated blood-stage malaria vaccine
Sign Up to like & getrecommendations! Published in 2021 at "BMC Medicine"
DOI: 10.1186/s12916-021-02150-x
Abstract: Background There is a clear need for novel approaches to malaria vaccine development. We aimed to develop a genetically attenuated blood-stage vaccine and test its safety, infectivity, and immunogenicity in healthy volunteers. Our approach was… read more here.
Keywords: attenuated blood; blood stage; malaria vaccine; genetically attenuated ... See more keywords
New gorilla adenovirus vaccine vectors induce potent immune responses and protection in a mouse malaria model
Sign Up to like & getrecommendations! Published in 2017 at "Malaria Journal"
DOI: 10.1186/s12936-017-1911-z
Abstract: BackgroundA DNA-human Ad5 (HuAd5) prime-boost malaria vaccine has been shown to protect volunteers against a controlled human malaria infection. The potency of this vaccine, however, appeared to be affected by the presence of pre-existing immunity… read more here.
Keywords: pycsp; gorilla; malaria vaccine; vaccine vectors ... See more keywords
Factors associated with malaria vaccine uptake in Sunyani Municipality, Ghana
Sign Up to like & getrecommendations! Published in 2021 at "Malaria Journal"
DOI: 10.1186/s12936-021-03857-1
Abstract: Background Malaria continues to be a major disease of public health concern affecting several million people worldwide. The World Health Organization (WHO) started a pilot study on a malaria vaccine (RTS,S) in Ghana and two… read more here.
Keywords: sunyani municipality; factors associated; malaria vaccine; vaccine uptake ... See more keywords
The Power of Malaria Vaccine Trials Using Controlled Human Malaria Infection
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DOI: 10.1371/journal.pcbi.1005255
Abstract: Controlled human malaria infection (CHMI) in healthy human volunteers is an important and powerful tool in clinical malaria vaccine development. However, power calculations are essential to obtain meaningful estimates of protective efficacy, while minimizing the… read more here.
Keywords: vaccine trials; controlled human; power; malaria infection ... See more keywords
Malaria vaccine candidates displayed on novel virus-like particles are immunogenic and induce transmission-blocking activity
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DOI: 10.1371/journal.pone.0221733
Abstract: The development of effective malaria vaccines remains a global health priority. Currently, the most advanced vaccine, known as RTS,S, has only shown modest efficacy in clinical trials. Thus, the development of more efficacious vaccines by… read more here.
Keywords: transmission; malaria vaccine; vaccine candidates; transmission blocking ... See more keywords
“I would have to sell things in order to get the money”: A qualitative exploration of willingness to pay for the RTS,S/AS01 malaria vaccine in the Volta region, Ghana
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0268009
Abstract: Background Malaria morbidity and mortality remain a challenge in Ghana. A promising childhood vaccine is being piloted in Ghana, however with the loss of its low-income status, Ghana is losing associated donor co-funding. User fees… read more here.
Keywords: ghana; rts as01; malaria vaccine; willingness pay ... See more keywords